Enfuvirtide Acetate CAS NO.159519-65-0

Enfuvirtide Acetate CAS NO.159519-65-0

Enfuvirtide Acetate CAS NO.159519-65-0

Enfuvirtide Acetate CAS NO.159519-65-0

Enfuvirtide Acetate CAS NO.159519-65-0

Enfuvirtide Acetate is a synthetic 36-amino acid peptide salt form of the first-in-class HIV fusion inhibitor, widely utilized as a critical active pharmaceutical ingredient (API) in antiretroviral therapy. Originally approved by the FDA in 2003 under the brand name Fuzeon, this acetate formulation enhances the stability and solubility profile of the peptide, making it suitable for pharmaceutical manufacturing and preclinical research applications. It is specifically designed for use in combination regimens to manage HIV-1 infection in treatment-experienced patients, offering a unique mechanism that sets it apart from traditional enzyme inhibitors like reverse transcriptase or protease inhibitors.



TECHNICAL SPECIFICATIONS


Item
Specification
Product Name
Enfuvirtide Acetate
CAS NO.
159519-65-0
Appearance
White to off-white lyophilized powder
Molecular Formula
C204H301N51O64
Molecular Weight
4492.01 g/mol
Purity (RP-HPLC)
≥ 98.0%
Solubility
Soluble in water; slightly soluble in acidic solutions; insoluble in organic solvents
Endotoxin≤5 EU/mg
Biological Activity
Inhibits HIV-1 entry into CD4+ T cells via gp41-mediated fusion blockade
Storage Conditions
Store at 2–8°C, protected from light and moisture; stable for 24 months
Stock Location
Stock in USA
MOQ
1g


1.MECHANISM OF ACTION

Enfuvirtide Acetate functions as an HIV-1 fusion inhibitor by precisely targeting the viral envelope glycoprotein gp41. It acts as a biomimetic decoy that mimics the HR2 domain of gp41, competitively binding to the HR1 region on the virus. This high-affinity binding sterically hinders the formation of the six-helix bundle structure required for the fusion of the viral membrane with the host CD4+ cell membrane. By blocking this crucial conformational change, the peptide effectively prevents viral entry into human cells, halting the infection cycle at its earliest stage without affecting intracellular processes.

upload/attachment/image/202603/31/1774928139d0f1f48194d6c4a4726c8fa605ad1593_local.png

2.PRODUCT INDICATIONS

This product is indicated for the treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection in combination with other antiretroviral agents. It is primarily reserved for treatment-experienced adults and pediatric patients (aged 6 years and above) who exhibit evidence of ongoing viral replication despite extensive therapy, and who harbor HIV-1 strains resistant to multiple drug classes. Enfuvirtide Acetate serves as a vital salvage therapy component for managing multidrug-resistant HIV, providing a new therapeutic option for populations with limited treatment alternatives due to resistance or intolerance issues.

upload/attachment/image/202603/31/1774928270ce19a141592ccafb6267ba640211fc6b_local.png

3.CLINICAL EFFICACY OF PRODUCT

Clinical trials, including the pivotal TORO studies, have demonstrated that subcutaneous Enfuvirtide significantly increases CD4 cell counts and reduces viral load when added to an optimized background regimen in heavily pretreated patients. Over 48 weeks of treatment, the addition of Enfuvirtide resulted in a significantly higher proportion of patients achieving undetectable viral loads compared to optimized therapy alone. Its unique extracellular mechanism ensures no cross-resistance with existing drug classes, making it highly effective against resistant strains and establishing it as a cornerstone of rescue therapy for advanced HIV disease.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.


Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.


We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards


Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

upload/attachment/image/202603/11/17731937213fbed5ed3f3869d1613bb629f6365f21_local.png


5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

upload/attachment/image/202601/20/1768872924be74a0641f7ddbf20e541c97f2066c5c_local.jpg


Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.


We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.


Hot Tags:Enfuvirtide Acetate, Fuzeon, T-20, DP178, HIV fusion inhibitor, gp41 inhibitor, antiretroviral peptide, HIV treatment, research peptide, antiviral agent, pharmaceutical API, CAS 159519-65-0, buy Enfuvirtide, Supplier, Manufacturer, Bulk order,  Pharmaceutical.


If you have any product requirements, please send an email to:info@huanqiukeji9.com;whatsapp:85246842553

Premium API Oxandrolone Ucinky Manufacturing
May 25, 26
Premium API Oxandrolone Ucinky Manufacturing
Premium API Oxandrolone Ucinky Manufacturing Leading global supplier of high-purity chemical raw materials for pharmaceutical grade Oxandrolone Ucinky, combining precision engineering with industrial scale. 5000 kg Annual Output 120 Countries Served 5 Days Sample Lead Time 99.7 On-Time Delivery Industrial Precision Pure Chemical Synthesis Engineering the future of pharmaceutical intermediates with unmatched stability. Our facility stands as a global leader in the oxandrolone ucinky sector, utilizing CRYOGENIC CRYSTALLIZATION and advanced chromatography to ensure an assay purity exceeding 99.8. We integrate a fully automated closed-loop system that eliminates human error and contamination.
Clinical Benefits and Applications of Oxandrolone Therapy
May 22, 26
Clinical Benefits and Applications of Oxandrolone Therapy
Oxandrolone therapy represents a sophisticated intersection of endocrine science and regenerative medicine, primarily utilized to address muscle wasting and metabolic dysfunction. In the global pharmaceutical landscape, this specific approach to androgen therapy is valued for its unique ability to promote protein synthesis while exhibiting a lower androgenic profile compared to traditional steroids, making it a critical tool for patients recovering from severe trauma or chronic illness. From a clinical perspective, understanding the nuances of oxandrolone therapy is essential for optimizing patient outcomes in weight gain and tissue repair.
Clinical Benefits and Production of Oxandrolone Steroid
May 20, 26
Clinical Benefits and Production of Oxandrolone Steroid
The global pharmaceutical landscape has seen a significant rise in the demand for highly specialized anabolic agents, among which the oxandrolone steroid stands out due to its unique chemical profile and therapeutic versatility. As a modified version of dihydrotestosterone, this compound provides a potent means of addressing muscle wasting and metabolic deficits, making it a critical asset in both clinical rehabilitation and advanced physiological research. Understanding the nuances of this synthetic compound is essential for healthcare providers and researchers alike, as it balances efficacy with a relatively lower androgenic profile compared to other steroids.

If you are interested in our products, you can choose to leave your information here, and we will be in touch with you shortly.