Name: Etelcalcetide CAS 1262780-97-1 | Effective Calcium Regulation
Availability: InStock
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Etelcalcetide CAS NO.1262780-97-1

Etelcalcetide is a second-generation intravenous calcimimetic peptide specifically engineered for the management of secondary hyperparathyroidism (SHPT) in adults undergoing hemodialysis. Marketed under the brand Parsabiv®, it features a unique D-amino acid structure that confers metabolic stability and a long-acting profile, allowing for convenient tri-weekly administration directly into the dialysis circuit at the end of each session. This product is a critical therapeutic option for nephrologists and dialysis centers aiming to achieve stringent parathyroid hormone (PTH) control without the pill burden associated with oral therapies.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Etelcalcetide
CAS NO.	1262780-97-1
Appearance	Lyophilized white to off-white powder
Molecular Formula	C38H73N21O10S2
Molecular Weight	Approximately 1048.25 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water (≥100 mg/mL), slightly soluble in DMSO; insoluble in ethanol and non-polar solvents
Endotoxin	< 1.0 EU/mg
Biological Activity	Allosteric activator of the calcium-sensing receptor (CaSR); reduces parathyroid hormone (PTH) levels in patients with secondary hyperparathyroidism.
Storage Conditions	Store at - 20°C or below, protected from light. Avoid repeated freeze - thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Etelcalcetide functions as an allosteric modulator of the calcium-sensing receptor (CaSR) on the surface of parathyroid cells. By binding covalently to the extracellular domain of the receptor, it increases the sensitivity of the gland to extracellular calcium, thereby suppressing the secretion of parathyroid hormone (PTH). This mechanism effectively lowers both PTH and serum calcium levels, addressing the core pathophysiology of SHPT in chronic kidney disease without promoting phosphate retention or increasing fibroblast growth factor 23 (FGF23), unlike traditional vitamin D analogs.

2.PRODUCT INDICATIONS

This product is indicated exclusively for the treatment of secondary hyperparathyroidism in adult patients with chronic kidney disease who are on maintenance hemodialysis. It is particularly suited for patients with uncontrolled PTH levels despite standard care, those intolerant to oral calcimimetics due to gastrointestinal side effects, and clinical scenarios where adherence to oral medication is a concern. It is not recommended for patients not on dialysis or for the treatment of primary hyperparathyroidism.

3.CLINICAL EFFICACY OF PRODUCT

Clinical trials and real-world studies have consistently demonstrated that Etelcalcetide produces a rapid and sustained reduction in intact PTH (iPTH) levels, with a significant proportion of patients achieving target ranges (e.g., >50% reduction from baseline). Long-term data confirm its efficacy in also lowering serum phosphate and the calcium-phosphate product (Ca×P), key risk factors for vascular calcification. While effective, its use requires careful monitoring for hypocalcemia, a common adverse effect managed through dose titration.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: Etelcalcetide #Parsabiv #Calcimimetic #SecondaryHyperparathyroidism #SHPT #Hemodialysis #CKD #RenalResearch #PeptideAPI

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