FITC-LC-Myelin Basic Protein Peptide Substrate
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | FITC-LC-Myelin Basic Protein Peptide Substrate |
| CAS NO. | |
| Appearance | Light yellow to yellow lyophilized powder (due to FITC conjugation) |
| Molecular Formula | C66H92N20O17S |
| Amino Acid Sequence | Customizable (common MBP‑derived sequences, e.g., residues 84‑104: ENPVVHFFKNIVTPRTPPPSQ) |
| Molecular Weight | 1325.4g/mol |
| Purity (RP-HPLC) | ≥90‑95% (fluorescent‑labeled peptide standard) |
| Solubility | Soluble in DMSO, DMF, PBS, or aqueous buffers (pH 7‑8) |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Fluorescent‑labeled peptide substrate for kinase assays (e.g., MAPK, PKC), immunofluorescence, or cell‑penetration studies; derived from myelin basic protein epitopes. |
| Storage Conditions | Store at –20°C protected from light and moisture; avoid repeated freeze‑thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1mg |
1.MECHANISM OF ACTION
The peptide acts as a selective substrate for target kinases, such as MAPK or PKC, which phosphorylate specific serine/threonine residues within the myelin basic protein (MBP) sequence. The FITC (fluorescein isothiocyanate) label, attached via a flexible LC (long‑chain) linker, allows fluorescence‑based detection of phosphorylation, facilitating high‑throughput kinase activity assays and imaging studies.
2.PRODUCT INDICATIONS
This substrate is widely used in kinase activity profiling, signal‑transduction pathway analysis, and drug‑discovery screening. It is also employed in studies of myelin biology, demyelinating diseases (e.g., multiple sclerosis), and neuronal development, providing a sensitive tool for quantitative phosphorylation measurement.
3.CLINICAL EFFICACY OF PRODUCT
While not intended for direct clinical application, this peptide substrate has proven valuable in preclinical research for identifying kinase inhibitors, elucidating disease‑relevant signaling cascades, and supporting the development of therapeutic strategies for myelin‑associated disorders. Its reliability in assay systems contributes to translational studies aimed at novel drug discovery.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
