Fmoc-D-2-(5-bromothienyl)alanine CAS NO.220497-83-6

Fmoc-D-2-(5-bromothienyl)alanine CAS NO.220497-83-6

Fmoc-D-2-(5-bromothienyl)alanine CAS NO.220497-83-6

Fmoc-D-2-(5-bromothienyl)alanine CAS NO.220497-83-6

Fmoc-D-2-(5-bromothienyl)alanine CAS NO.220497-83-6

Fmoc-D-2-(5-bromothienyl)alanine is a high-purity non-natural amino acid building block designed for advanced solid-phase peptide synthesis (SPPS) and medicinal chemistry research. It features an Fmoc-protected amino group and a unique 5-bromothiophene side chain, which serves as a versatile handle for further functionalization via cross-coupling reactions. This D-configuration derivative is essential for constructing peptidomimetics and bioactive peptide sequences, offering researchers a tool to enhance the structural diversity and pharmacological properties of synthetic peptides in drug discovery.



TECHNICAL SPECIFICATIONS


Item
Specification
Product Name
Fmoc-D-2-(5-bromothienyl)alanine
CAS NO.
220497-83-6
Appearance
White to off-white powder
Molecular Formula
C22H18BrNO4S
Molecular Weight
472.35 g/mol
Purity (RP-HPLC)
≥ 98.0%
Solubility
Soluble in DMF, DMSO; sparingly soluble in water, methanol
Endotoxin< 0.5 EU/mg
Biological Activity
Research use only; not for human or animal therapeutic applications
Storage Conditions
Store at -20°C, protected from light and moisture
Stock Location
Stock in USA
MOQ
1g


1.MECHANISM OF ACTION

As a chemical building block rather than a direct-acting pharmaceutical, this compound's "mechanism" lies in its synthetic utility. The Fmoc group acts as an orthogonal protecting group for the alpha-amino function, which can be cleanly removed under mild basic conditions (e.g., piperidine) during SPPS to allow for sequential peptide chain elongation without affecting the bromothiophene side chain. The bromine atom on the thiophene ring provides a reactive site for post-synthetic modifications, such as Suzuki or Sonogashira cross-coupling reactions, enabling the late-stage diversification of peptide structures to optimize their interaction with biological targets.

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2.PRODUCT INDICATIONS

This product is indicated for research and development applications in chemical biology and drug discovery. It is specifically suited for the synthesis of thiophene-based peptidomimetics, constrained peptide cycles, and novel peptide therapeutics where the introduction of a hydrophobic, halogenated aromatic ring is desired. Typical users include medicinal chemists and peptide scientists in academic institutions and pharmaceutical R&D departments who require high-quality, chiral-pure (D-configuration) amino acid derivatives to study structure-activity relationships or develop enzyme inhibitors and receptor modulators.

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3.CLINICAL EFFICACY OF PRODUCT

While this specific compound is a research-grade intermediate and not a finished drug, its efficacy is demonstrated through its contribution to producing biologically active peptides. Peptides synthesized using this building block have shown promising preclinical efficacy in developing potent inhibitors for proteases and other enzymes involved in disease pathways. Its structural features help improve the metabolic stability and binding affinity of lead compounds, making it a valuable asset in the early-stage development of potential therapeutics for inflammatory diseases and cancer.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.


Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.


We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards


Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.


We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.


HotTags:FmocAminoAcid, PeptideSynthesis, Bromothiophene, AminoAcidDerivative, DrugDiscovery, MedicinalChemistry, SPPS, ChemicalBiology, NonNaturalAminoAcid, BuildingBlock, Supplier, Manufacturer, Bulk order,  Pharmaceutical.


If you have any product requirements, please send an email to:info@huanqiukeji9.com;whatsapp:85246842553

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