Fmoc-D-Glu(OtBu)-OH CAS NO. 142995-25-9
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Fmoc-D-Glu(OtBu)-OH |
| CAS NO. | 142995-25-9 |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C₂₄H₂₇NO₆ |
| Molecular Weight | 425.5 g/mol |
| Amino Acid Sequence | Fmoc-D-Glu(OtBu)-OH (Fmoc-protected D-Glutamic acid γ-tert-butyl ester) |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | Soluble in DMF, DMSO, and dichloromethane; slightly soluble in methanol; insoluble in water |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Protected D-glutamic acid derivative used as a chiral building block in solid-phase peptide synthesis, especially for introducing D-amino acids into peptide sequences in drug discovery and biochemical research. |
| Storage Conditions | Store at 2-8°C, protected from light and moisture. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This compound functions as a key reagent in solid-phase peptide synthesis, where the Fmoc group protects the amino terminus and the tert-butyl ester shields the carboxyl group. These protections enable controlled, sequential coupling in peptide chain assembly, allowing for the precise incorporation of D-glutamic acid into target sequences to modulate peptide stability and bioactivity.
2.PRODUCT INDICATIONS
Fmoc-D-Glu(OtBu)-OH is widely used in the synthesis of therapeutic peptides, peptidomimetics, and biochemical probes. It is particularly valuable in research focused on developing enzyme inhibitors, receptor ligands, and antimicrobial peptides, as well as in structural studies of peptide folding and function.
3.CLINICAL EFFICACY OF PRODUCT
4.DELIVERY & SHIPPING
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Professional and Secure Packaging
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