📝 Product Description

Fmoc-Thr(tBu)-Phe-OH is a heterodimeric dipeptide building block specifically designed for Fmoc-based solid-phase peptide synthesis (SPPS). It consists of an L-Threonine residue linked to an L-Phenylalanine residue. The alpha-amino group is protected by the standard base-labile Fmoc (9-fluorenylmethoxycarbonyl) group. The beta-hydroxyl group on the Threonine side chain is protected with a tert-butyl (tBu) ether group, ensuring stability during coupling reactions while allowing for acid-labile deprotection. This molecule combines the polar nature of threonine with the hydrophobic character of phenylalanine.

🔬 Primary Application

This compound is widely used in the stepwise assembly of complex peptides and proteins. It serves as a crucial intermediate for introducing a Thr-Phe sequence into a growing peptide chain. It is particularly valuable in the research and development of peptide-based pharmaceuticals, enzyme inhibitors, and structural studies where the specific interaction between polar and aromatic residues is required. The tBu protection prevents side-chain interference during the synthesis process.

📦 Storage Conditions

Temperature: Store at -20°C.

Atmosphere: Keep under an inert gas atmosphere (such as Argon or Nitrogen) if possible.

Environment: Protect from light and moisture.

Shelf Life: Typically stable for 12-24 months when stored correctly.

⚠️ Handling and Safety Notes

Sensitivity: This compound is sensitive to moisture, heat, and strong acids/bases. The tBu protecting group is stable to base but is removed by strong acids like TFA (Trifluoroacetic acid), while the Fmoc group is removed by piperidine.

Solubility: Generally soluble in polar aprotic solvents like DMF (Dimethylformamide) and DMSO (Dimethyl sulfoxide).

Usage: For research use only. Not intended for human or veterinary use, or for diagnostic purposes.

Precaution: Standard laboratory safety practices should be followed. Wear appropriate personal protective equipment (PPE), including lab coats, gloves, and eye protection, when handling this chemical.