G209-2M; gp100 (209-217)
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | G209-2M; gp100 (209-217) |
| CAS NO. | |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C47H74N10O14S |
| Molecular Weight | 1035.24g/mol |
| Amino Acid Sequence | IMDQVPFSV (human gp100₉₀₀‑₃₁₇ epitope; may include modifications such as methylation at Met⁺, D-amino acid substitution, or C-terminal amidation) |
| Purity (RP-HPLC) | ≥95.0% |
| Solubility | Soluble in DMSO, PBS, or other aqueous buffers; may require sonication or gentle heating |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | HLA-A*0201-restricted tumor-associated antigen peptide; used in cancer vaccine research, T-cell activation studies, and immunotherapy development for melanoma. |
| Storage Conditions | Store at –20°C, protected from light and moisture. For long-term storage, recommend –80°C. |
| Stock Location | Stock in USA |
| MOQ | 10mg |
1.MECHANISM OF ACTION
G209-2M; gp100 (209-217) functions as a tumor-associated antigen peptide that is presented by HLA-A*0201 molecules on antigen-presenting cells. This presentation activates specific cytotoxic T lymphocytes (CTLs), leading to targeted immune responses against melanoma and other cancers expressing the gp100 antigen.
2.PRODUCT INDICATIONS
This peptide is primarily used in research focused on melanoma immunotherapy, cancer vaccine development, and T-cell activation studies. It is also employed in immunological assays, epitope mapping, and preclinical evaluation of adoptive cell therapies.
3.CLINICAL EFFICACY OF PRODUCT
Preclinical and clinical studies have shown that vaccines and therapies utilizing the gp100 (209-217) epitope can induce antigen-specific T-cell responses and contribute to tumor regression in melanoma patients. Its role in enhancing immune recognition of cancer cells supports its potential in combination immunotherapy approaches.
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Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
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