Galanin (2-11) CAS NO.367518-31-8
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Galanin (2‑11) |
| CAS NO. | 367518‑31‑8 |
| Appearance | White to off‑white lyophilized powder |
| Molecular Formula | C54H81N13O14 |
| Molecular Weight | 1136.33g/mol |
| Amino Acid Sequence | Trp‑Thr‑Leu‑Asn‑Ser‑Ala‑Gly‑Tyr‑Leu‑Leu (corresponding to galanin residues 2‑11) |
| Purity (RP-HPLC) | ≥95% (typical for synthetic peptide) |
| Solubility | Soluble in water, dilute acetic acid, and aqueous buffers |
| Endotoxin | <1.0 EU/mg (if for in vivo use) |
| Biological Activity | Galanin receptor ligand; modulates neurotransmitter release, feeding behavior, and nociception in neurobiological research. |
| Storage Conditions | Store at –20°C, protected from light and moisture. For long‑term storage, recommend –80°C. |
| Stock Location | Stock in USA |
| MOQ | 1mg |
1.MECHANISM OF ACTION
This peptide acts as a selective ligand for galanin receptors (GalR1, GalR2, and GalR3), modulating intracellular signaling pathways such as inhibition of adenylyl cyclase and regulation of potassium and calcium channels. This interaction influences neuronal excitability, neurotransmitter release, and various central and peripheral physiological processes.
2.PRODUCT INDICATIONS
Galanin (2-11) is primarily used in scientific research to investigate its role in pain perception, feeding behavior, mood regulation, and cognitive function. It is a valuable tool for studying neurological disorders, metabolic conditions, and the development of novel therapeutic agents targeting the galaninergic system.
3.CLINICAL EFFICACY OF PRODUCT
While not yet approved for clinical use, preclinical studies indicate that Galanin (2-11) and related analogues show promise in modulating pain sensitivity, reducing seizure activity, and influencing appetite and hormonal responses. Its efficacy in animal models supports its potential as a lead compound for future therapeutic development in areas such as chronic pain and epilepsy.
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