Name: Galanin Message Associated Peptide (44-59) Amide CAS 125455-59-6
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Galanin Message Associated Peptide (44-59) amide CAS NO.125455-59-6

Galanin Message Associated Peptide (44-59) amide (CAS: 125455-59-6), also known as GALP (1-16) or GALP(44-59)-NH2, is a synthetic 16-amino acid peptide fragment corresponding to residues 44-59 of the human Galanin-like Peptide (GALP) precursor, with a C-terminal amidation. This bioactive fragment is part of the galanin peptide family and exhibits distinct biological activities, particularly in metabolic regulation and neuroendocrine function.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Galanin Message Associated Peptide (44-59) amide
CAS NO.	125455-59-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C61H100N18O25
Molecular Weight	1485.58 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥5 mg/mL) and dilute aqueous acids; sparingly soluble in organic solvents like DMSO
Endotoxin	< 1.0 EU/mg
Biological Activity	Modulates galaninergic system signaling; exhibits neuromodulatory effects in central nervous system tissues
Storage Conditions	Store at -20°C to -80°C in a dry environment; avoid repeated freeze-thaw cycles. Reconstituted solutions are stable at 4°C for 3–5 days or -20°C for 1–2 months.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

GALP (44-59) amide exerts its effects primarily through selective activation of galanin receptor subtypes, with a preferential affinity for GalR2. Upon binding, this peptide activates Gq/11 protein-coupled signaling pathways, leading to phospholipase C (PLC) activation, subsequent inositol trisphosphate (IP3) production, and diacylglycerol (DAG) accumulation. This cascade results in the mobilization of intracellular calcium stores and activation of protein kinase C (PKC).

2.PRODUCT INDICATIONS

Metabolic Disorder Research: Investigating the role of GALP fragments in feeding behavior, body weight regulation, and energy expenditure.

Neuroscience Studies: Exploring central nervous system effects on appetite circuits and neuroendocrine integration.

Receptor Specificity Assays: Differentiating signaling pathways and functions between galanin receptor subtypes (GalR1, GalR2, GalR3).

Endocrinology Research: Studying its effects on the release of hypothalamic and pituitary hormones.

Signal Transduction Studies: Analyzing Gq/11-mediated intracellular calcium mobilization and PKC activation.

Obesity and Diabetes Models: Utilizing this peptide in preclinical models to study potential therapeutic targets for metabolic diseases.

3.CLINICAL EFFICACY OF PRODUCT

Preclinical animal studies involving central administration of GALP or related peptides have demonstrated significant effects on food intake, body weight, and metabolic rate, often showing an initial orexigenic (appetite-stimulating) effect followed by a longer-term anorexigenic (appetite-suppressing) action.

Research suggests that GALP's effects are mediated through interaction with leptin signaling pathways, making it a peptide of interest in obesity research.

To date, there are no approved clinical therapies or published human trials utilizing GALP (44-59) amide. Its clinical efficacy and safety profile remain undefined, and its use is confined to experimental laboratory investigations.

Future translational potential would depend on extensive pharmacological optimization, safety studies, and clinical trials to evaluate its utility in treating metabolic disorders.

4.DELIVERY & SHIPPING

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