Garcinone D CAS NO.107390-08-9
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Garcinone D |
| Synonyms | / |
| CAS NO. | 107390-08-9 |
| Appearance | Light yellow to yellow crystalline solid / Powder |
| Molecular Formula | C24H28O7 |
| Molecular Weight | 428.47 g/mol |
| Amino Acid Sequence | / |
| Purity (RP-HPLC) | ≥ 98.0% |
| Purity (SEC-HPLC) | ≥ 99.0% (monomer content) |
| Solubility | Soluble in DMSO (≥ 100 mg/mL); insoluble in water |
| Endotoxin | Not applicable (Non-endotoxin producing agent) |
| Biological Activity | A natural xanthone promoting proliferation of C17.2 neural stem cells via STAT3/Cyclin D1 and Nrf2/HO-1 pathways; exhibits potential neuroprotective and antioxidant properties |
| Storage Conditions | Store at 2-8°C, protected from light; stable for 2 years under proper storage conditions |
| Stock Location | Stock in USA |
| MOQ | 1g |
Garcinone D
1.MECHANISM OF ACTION
Garcinone D exerts its effects by activating the STAT3/Cyclin D1 and Nrf2/HO-1 signaling pathways, which are crucial for cell proliferation and oxidative stress defense. It enhances the phosphorylation of STAT3 and upregulates Cyclin D1, thereby promoting cell cycle progression. Additionally, it stabilizes mitochondrial function and reduces reactive oxygen species (ROS) levels, mitigating amyloid β42-induced neurotoxicity and protecting neurons from apoptosis.
2.PRODUCT INDICATIONS
3.CLINICAL EFFICACY OF PRODUCT
In preclinical studies, Garcinone D has demonstrated significant efficacy in enhancing cell viability and reducing apoptotic markers in neuronal cells exposed to amyloid β42. It has shown promise in maintaining the stemness of hematopoietic stem cells during long-term culture, which is critical for successful stem cell transplantation. These findings highlight its potential as a therapeutic agent for neurodegenerative disorders and as a supplement for stem cell-based therapies.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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