Gastrin Releasing Peptide, human CAS NO.93755-85-2
Gastrin Releasing Peptide, human CAS NO.93755-85-2
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Gastrin Releasing Peptide, human |
| CAS NO. | 93755-85-2 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₁₃₀H₂₀₄N₃₈O₃₁S₂ |
| Molecular Weight | 2859.4 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water (pH 4.0–7.0) or 0.1 M acetic acid; slightly soluble in DMSO (≤5 mg/mL) |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Binds to gastrin-releasing peptide receptor (GRPR, BB₂) with high affinity (Ki: 0.1–1 nM), stimulating gastrin release from G cells, increasing gastric acid secretion, and modulating smooth muscle contraction. Also involved in neurotransmission, immune response, and cancer progression (e.g., prostate, breast). |
| Storage Conditions | Lyophilized powder: Store at -20°C in a desiccated, light-protected container; avoid repeated freeze-thaw cycles. After reconstitution, aliquot and store at -80°C (stable for 6 months) or 2–8°C (stable for 1 week). |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
GRPR Activation: Binds to the gastrin-releasing peptide receptor (GRPR/BB₂) with high affinity (Ki: 0.1–1 nM), triggering Gq/11 protein-coupled signaling cascades.
Gastrin Secretion: Stimulates enterochromaffin-like (ECL) cells to release histamine, which in turn induces gastrin secretion from G cells in the stomach antrum, driving gastric acid production.
Smooth Muscle Contraction: Modulates gastrointestinal motility by activating GRPR on smooth muscle cells, enhancing peristalsis and sphincter relaxation.
Neurotransmission: Functions as a neurotransmitter/neuromodulator in the central and peripheral nervous systems, regulating pain perception, stress responses, and memory.
- Increases gastrin release by 3–5x in isolated rat G cells (ED₅₀: 0.5 nM).Enhances gastric acid output by 40–60% in pylorus-ligated rat models.Reduces pain responses in neuropathic pain models (spinal nerve ligation) by 30–50% (GRPR-mediated antinociception).
2.PRODUCT INDICATIONS
Gastroenterology Research: Studying gastric acid secretion mechanisms, peptic ulcer disease, and gastroesophageal reflux disorder (GERD).
Neuroscience Studies: Investigating neuromodulatory roles in anxiety, depression, epilepsy, and neurodegenerative diseases (e.g., Alzheimer’s).
Oncology Research: Targeting GRPR-positive tumors (e.g., prostate, breast, small cell lung cancer) for diagnostic imaging or radiopharmaceutical development.
3.CLINICAL EFFICACY OF PRODUCT
Therapeutic Potential: GRPR antagonists derived from this peptide show promise in treating GRPR-overexpressing cancers (e.g., prostate cancer) in early-phase clinical trials.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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