Ginsenoside Rb1 CAS NO.41753-43-9
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Ginsenoside Rb1 |
| CAS NO. | 41753-43-9 |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C₅₄H₉₂O₂ |
| Molecular Weight | 1109.29 g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | - Methanol: 9.80–10.20 mg/mL, clear, colorless to faintly yellow - DMSO: 10–145 mg/mL (sonication recommended) - Water: ≥33.33 mg/mL - DMF: 15 mg/mL - Ethanol: 0.1 mg/mL - PBS (pH 7.2): 1 mg/mL |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | - Inhibits Na⁺/K⁺-ATPase (IC₅₀ = 6.3±1.0 μM)- Modulates NF-κB/MAPK signaling, exerts anti-inflammatory effects- Neuroprotective, cardioprotective, and anti-diabetic activities- Promotes autophagy and mitophagy |
| Storage Conditions | - Powder: -20°C for 3 years; 4°C for 2 years- In solution: -80°C for 6 months; -20°C for 1 month- Protect from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
- Neuroprotection & Cognitive Enhancement: It protects neurons by reducing oxidative stress, inhibiting apoptosis, and suppressing neuroinflammation. It modulates neurotransmitter systems (e.g., cholinergic) and promotes neurogenesis and synaptic plasticity, potentially via activation of the PI3K/Akt and CREB signaling pathways. It also inhibits acetylcholinesterase (AChE) activity.
- Cardioprotection: It protects the heart from ischemia/reperfusion injury by reducing oxidative stress, inhibiting apoptosis in cardiomyocytes, and improving energy metabolism. It also promotes angiogenesis (formation of new blood vessels) via the PI3K/Akt/eNOS pathway.
- Anti-diabetic Effects: It improves insulin sensitivity, promotes glucose uptake in peripheral tissues, and protects pancreatic β-cells.
- Anti-inflammatory Action: It inhibits the production of pro-inflammatory cytokines (e.g., TNF-α, IL-1β, IL-6) by suppressing the NF-κB and MAPK pathways.
2.PRODUCT INDICATIONS
- Cardiovascular Research: Studies on myocardial infarction, heart failure, atherosclerosis, and angiogenesis.
- Metabolic Disease Research: For type 2 diabetes, obesity, and non-alcoholic fatty liver disease (NAFLD).
- Oncology Research: Investigating its role as an adjuvant in cancer therapy, focusing on reducing chemotherapy side effects, enhancing efficacy, and its direct anti-proliferative effects.
- Sports Science & Anti-fatigue Research: Studying its effects on physical performance, endurance, and recovery.
- Phytochemistry & Quality Control: As a primary reference standard for the authentication and standardization of ginseng roots, extracts, and commercial products.
3.CLINICAL EFFICACY OF PRODUCT
- Preclinical Efficacy: Extensive in vitro and in vivo studies have robustly demonstrated its neuroprotective, cardioprotective, anti-diabetic, and anti-fatigue effects in various animal models.
- Human Clinical Evidence (from Ginseng Extracts): While specific Rb1 intervention trials are rarer, standardized ginseng extracts (containing Rb1 as a major component) have shown clinical benefits in:
- Improving cognitive performance and memory in healthy adults and patients with cognitive impairment.
- Enhancing physical endurance and reducing fatigue.
- Improving glucose control and insulin sensitivity in type 2 diabetic patients.
- Improving erectile function and quality of life.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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