GIP, porcine
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | GIP, porcine |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C225H342N60O66S |
| Molecular Weight | 4975.66g/mol |
| Purity (RP-HPLC) | ≥95% |
| Solubility | Soluble in water (≥5 mg/mL) and dilute aqueous buffers (pH 7.0–8.0). |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Potent insulinotropic activity; stimulates insulin secretion in the presence of elevated glucose levels |
| Storage Conditions | Store at ≤-20°C in a desiccated environment, avoid repeated freeze-thaw cycles. Reconstituted solution. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Porcine GIP exerts its effects primarily by binding and activating the GIP Receptor (GIPR), a G-protein coupled receptor (GPCR) expressed on pancreatic beta cells, adipocytes, osteoblasts, and other tissues. Activation of GIPR is strongly glucose-dependent. In the pancreas, receptor binding stimulates Gs-protein-mediated activation of adenylate cyclase, leading to a sharp increase in intracellular cyclic AMP (cAMP).
- Porcine Metabolic Research: Studying the physiology of glucose homeostasis, insulin secretion, and lipid metabolism in swine models of diabetes, obesity, or metabolic syndrome.
- Comparative Incretin Biology: Investigating functional and structural similarities/differences between porcine and human incretin systems.
- Pancreatic Islet & Beta-Cell Studies: Using porcine islets or beta-cell lines to examine GIP-mediated potentiation of insulin secretion and beta-cell survival.
- Animal Physiology Studies: Administering to pigs to study its acute effects on gastric acid inhibition, insulin release, and postprandial metabolism.
2.PRODUCT INDICATIONS
- Physiological Role: As an incretin, it is a potent physiological stimulator of insulin secretion in a glucose-dependent manner, contributing significantly to postprandial glucose control.
- Therapeutic Target: The human GIP system is a key component of the most effective new class of diabetes drugs: dual GLP-1/GIP receptor agonists (e.g., Tirzepatide/Mounjaro®). Tirzepatide's inclusion of GIP receptor agonism is credited with superior efficacy in lowering blood glucose and reducing body weight compared to GLP-1-only agonists.
- Research Foundation: Studies using porcine GIP have been instrumental in elucidating the basic biology of the incretin system, paving the way for these clinical breakthroughs.
3.CLINICAL EFFICACY OF PRODUCT
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
