Glepaglutide CAS NO.914009-86-2
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Glepaglutide |
| CAS NO. | 914009-86-2 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C197H325N53O55 |
| Molecular Weight | 4316.01g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water or aqueous buffers. For best results, prepare a stock solution in sterile water or PBS and aliquot to avoid repeated freeze-thaw cycles. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Exhibits biological activity consistent with Glepaglutide. Specific activity may vary depending on the assay system and experimental conditions. |
| Storage Conditions | Store lyophilized powder at -20°C or below. For long-term storage, keep at -80°C. Protect from light and moisture. Reconstituted solutions should be stored at -20°C or -80°C in single-use aliquots. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Glepaglutide exerts its therapeutic effects by selectively activating the GLP-2 receptor, which is predominantly expressed in the gastrointestinal tract. This receptor activation stimulates the proliferation and inhibits the apoptosis of intestinal epithelial cells, leading to increased villus height and crypt depth—a process known as intestinal adaptation. The result is a significant expansion of the absorptive surface area of the intestine, improved barrier function, and enhanced absorption of fluids and nutrients, directly countering the pathophysiology of SBS.
2.PRODUCT INDICATIONS
Glepaglutide is indicated for the treatment of adult patients with short bowel syndrome (SBS) who are dependent on parenteral support. It is specifically beneficial for individuals who have undergone extensive intestinal resection and struggle with chronic malabsorption, aiming to reduce their need for intravenous fluids and nutrition. This product is a critical therapeutic option for improving intestinal function and nutritional autonomy in this specific patient population.
3.CLINICAL EFFICACY OF PRODUCT
In Phase 3 clinical trials, glepaglutide demonstrated significant efficacy in reducing the volume and number of days of parenteral support required by SBS patients. A substantial proportion of patients achieved at least a 20% reduction in weekly parenteral support volume. The therapy also showed positive effects on intestinal absorption, as measured by increased wet weight absorption and improved markers of nutritional status. Its safety profile was manageable, with the most common adverse events being injection site reactions and gastrointestinal symptoms.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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