gp100 (614-622)
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | gp100 (614-622) |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C56H101N19O11S |
| Molecular Weight | g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in DMSO, PBS (pH 7-8), or physiological saline. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | The HLA-A*0201-restricted CTL epitope (corresponding to positions 614-622) of human melanoma-associated antigen gp100/pMel 17 can induce a specific CD8+ T cell immune response, and can be used for tumor immunology, vaccines and T cell therapy research. |
| Storage Conditions | Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
gp100 (614-622) functions as a tumor-associated antigen peptide that binds to HLA-A0201 molecules on antigen-presenting cells (APCs), forming peptide-MHC complexes that are recognized by T cell receptors (TCRs) on CD8+ T cells. This specific interaction triggers T cell activation, proliferation, and differentiation into cytotoxic T lymphocytes (CTLs). The activated CTLs then recognize and eliminate tumor cells expressing the gp100 antigen through perforin/granzyme-mediated cytotoxicity and cytokine release (such as IFN-γ). The peptide's immunogenicity is characterized by its ability to induce T cell responses in HLA-A0201-positive systems, making it valuable for both in vitro and in vivo immunological studies.
2.PRODUCT INDICATIONS
3.CLINICAL EFFICACY OF PRODUCT
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
