GPC3 (144 – 152)
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | GPC3 (144‑152) |
| CAS NO. | |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C52H69N9O15 |
| Molecular Weight | 1060.18g/mol |
| Amino Acid Sequence | FVGEFFTDV (human GPC3 residues 144‑152, HLA‑A*24:02‑restricted epitope) |
| Purity (RP-HPLC) | ≥95.0% |
| Solubility | Soluble in DMSO, PBS, or sterile water (may require brief sonication) |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | HLA‑A*24:02‑restricted tumor‑associated antigen peptide; used in hepatocellular carcinoma (HCC) immunotherapy research, T‑cell activation studies, and cancer vaccine development. |
| Storage Conditions | Store at –20°C, protected from light and moisture. For long-term storage, recommend –80°C. |
| Stock Location | Stock in USA |
| MOQ | 10mg |
1.MECHANISM OF ACTION
GPC3 (144-152) acts as a tumor-associated antigen presented by HLA-A*24:02 molecules on antigen-presenting cells. This presentation activates cytotoxic T lymphocytes (CTLs), which then recognize and eliminate GPC3-positive cancer cells, initiating a specific anti-tumor immune response.
2.PRODUCT INDICATIONS
This peptide is used in the research and development of immunotherapies for hepatocellular carcinoma, including peptide-based vaccines and adoptive T-cell therapies. It is also applied in immunological assays, T-cell activation studies, and preclinical evaluation of combination treatment strategies for GPC3-expressing cancers.
3.CLINICAL EFFICACY OF PRODUCT
Preclinical studies and early-phase clinical trials indicate that GPC3-targeting peptides can induce antigen-specific T-cell responses and contribute to tumor control in HCC models. Its potential in enhancing immune-mediated tumor regression supports ongoing research into GPC3-directed immunotherapeutic approaches.
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
