Name: HBcAg (HBV) (18-27) Peptide – High Purity & Specificity
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HBcAg (HBV) (18 – 27)

HBcAg (HBV) (18-27) is a high-purity synthetic peptide representing the HLA-A0201-restricted cytotoxic T lymphocyte (CTL) epitope of Hepatitis B virus core antigen. This 10-amino acid peptide (FLPSDFFPSV) corresponds to residues 18-27 of the HBV core protein and serves as a key immunogenic epitope recognized by CD8⁺ T cells. Manufactured under stringent quality controls with HPLC-verified purity and comprehensive analytical documentation, this product provides researchers with a specialized tool for studying HBV-specific immune responses, T cell activation, and vaccine development. The peptide's high affinity for HLA-A0201 makes it particularly valuable for immunology research, T cell monitoring, and therapeutic vaccine evaluation in HLA-A*0201-positive individuals.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	HBcAg (HBV) (18 - 27)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C580H78N10O15
Molecular Weight	1155.33g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in DMSO, PBS (pH 7‑8)
Endotoxin	< 1.0 EU/mg
Biological Activity	The HLA-A*0201-restricted CTL epitope of hepatitis B virus core antigen (HBcAg) can induce HBV-specific CD8⁺ T cell immune responses, and can be used for HBV immunity research, vaccine development and T cell therapy.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

HBcAg (HBV) (18-27) functions as a major histocompatibility complex (MHC) class I-restricted epitope that is processed and presented by antigen-presenting cells. After uptake and proteolytic processing, the peptide binds to HLA-A0201 molecules on the cell surface, forming stable MHC-peptide complexes. These complexes are recognized by T cell receptors (TCRs) on CD8⁺ cytotoxic T lymphocytes, leading to T cell activation, proliferation, and effector functions including cytokine production and cytotoxic activity against HBV-infected cells. The peptide's specific sequence (FLPSDFFPSV) contains anchor residues that confer high binding affinity to HLA-A0201, making it an immunodominant epitope in HBV infection and vaccination contexts.

2.PRODUCT INDICATIONS

T Cell Activation Studies: Evaluation of CD8⁺ T cell activation, proliferation, and cytokine production

Vaccine Development: Assessment of vaccine-induced T cell responses and immunogenicity

Immune Monitoring: Detection and quantification of HBV-specific T cells using ELISPOT, MHC tetramer staining, or intracellular cytokine staining

TCR Screening: Identification and validation of T cell receptors specific for HBV epitopes

Therapeutic Vaccine Research: Development and testing of T cell-based immunotherapies for chronic HBV

HBV Immunology Research: Investigation of HBV-specific T cell responses and immune evasion mechanisms

3.CLINICAL EFFICACY OF PRODUCT

Sequence Accuracy: Verified 10-amino acid sequence (FLPSDFFPSV) corresponding to HBV core antigen 18-27

Biological Activity: Validated in T cell activation assays, MHC binding assays, and immune monitoring applications

Research Reproducibility: Consistent performance in functional assays across multiple batches

Quality Documentation: Certificate of Analysis provided with purity, mass spec, and analytical data

Technical Support: Access to application guidance for immunology research and T cell assays

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.