HBV core (107 – 115)
HBV core (107 – 115)
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | HBV core (107-115) |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C44H72N12O14S |
| Molecular Weight | 1025.19g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, dilute PBS (pH 7.2-7.4), 0.1% TFA aqueous solution |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Immunogenic 9-mer peptide fragment of HBV core capsid protein; a key epitope for eliciting anti-HBV cellular immune (T-cell) responses; used in HBV immunology research, vaccine candidate development, HBV diagnostic assay optimization and viral capsid assembly mechanism studies |
| Storage Conditions | Store at -20°C to -80°C in a sealed, dry container; protect from moisture and avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This peptide functions as a specific antigenic determinant for CD8+ cytotoxic T lymphocytes (CTLs). During viral replication in infected hepatocytes, intracellular proteasomes process the HBV core protein into short peptides. The core (107-115) epitope is transported into the endoplasmic reticulum, loaded onto HLA-A0201 molecules, and displayed on the cell surface. As an exogenous reagent, the synthetic peptide can be used to "pulse" antigen-presenting cells (APCs), facilitating its presentation via HLA-A0201. CTLs bearing T-cell receptors (TCRs) specific for this exact peptide-MHC complex recognize and bind to it.
- HBV-Specific T-Cell Response Analysis: Quantifying and functionally characterizing core (107-115)-specific CD8+ T cells in HLA-A*0201-positive individuals with acute, chronic, or resolved HBV infection using assays such as enzyme-linked immunospot (ELISPOT), intracellular cytokine staining (ICS), or HLA tetramer staining.
- Therapeutic Vaccine Development: Evaluating the immunogenicity and efficacy of this epitope as a component in peptide-based, dendritic cell-based, or viral-vectored therapeutic vaccine strategies aimed at restoring functional T-cell responses in chronic hepatitis B.
- Immune Escape Monitoring: Investigating the impact of core gene mutations within or flanking this epitope on T-cell recognition, a key mechanism of viral persistence under immune pressure.
- T-Cell Receptor (TCR) Discovery & Engineering: Isolating natural TCRs specific for this epitope from patient samples or validating the specificity of engineered TCRs intended for adoptive T-cell therapy (ACT) against HBV.
- Comparative Epitope Studies: Assessing the immunodominance hierarchy and functional avidity of T-cell responses against different HBV core epitopes (e.g., core18-27, core141-151) in the same individual.
- Biomarker Research: Correlating the magnitude and quality of core (107-115)-specific T-cell responses with clinical outcomes such as viral load, HBeAg seroconversion, HBsAg loss, or liver disease progression.
2.PRODUCT INDICATIONS
- Research & Diagnostic Tool Efficacy: Its efficacy is its reliable use in detecting and measuring a specific, clinically relevant antiviral T-cell response. Robust and multispecific CTL responses against core epitopes, including (107-115), are strongly associated with viral clearance in acute infection and with immune control in chronic infection.
- Therapeutic Vaccine Target: This epitope is a prime candidate component in investigational therapeutic vaccines for chronic HBV. The goal of these vaccines is to stimulate or broaden functional CTL responses to achieve a functional cure. Clinical trials have incorporated core epitopes to assess immunogenicity.
- Immune Monitoring in Clinical Trials: In research settings, this peptide is used to monitor the restoration of antiviral T-cell function in patients undergoing novel immunotherapies (e.g., TLR agonists, checkpoint inhibitors, therapeutic vaccines) combined with standard antiviral drugs (nucleos(t)ide analogs).
- Pathogenesis Insight: Studying T-cell responses to this epitope helps understand the mechanisms of T-cell exhaustion and functional impairment in the tolerogenic liver environment during chronic HBV infection, guiding strategies to reverse exhaustion.
3.CLINICAL EFFICACY OF PRODUCT
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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