High Purity Angiotensin A CAS 34273126 China Suppliers and Factory
Angiotensin A (CAS NO. 34273-12-6) is a premium research-grade decapeptide serving as a critical biologically inactive prohormone. It is the primary substrate for Angiotensin-Converting Enzyme (ACE), undergoing enzymatic cleavage to generate the potent vasoactive peptide Angiotensin II. This essential conversion triggers systemic physiological responses, including vasoconstriction and aldosterone synthesis, making Angiotensin A an indispensable tool for studying the Renin-Angiotensin-Aldosterone System (RAAS).
Engineered for high-precision laboratory applications, our Angiotensin A is produced under strict quality controls to ensure a purity of ≥99.0%. It is specifically indicated for pharmaceutical drug discovery, biochemical assay development, and the calibration of mass spectrometry and HPLC methods. By providing a stable and reliable substrate, it enables researchers to quantify ACE activity and evaluate the efficacy of antihypertensive candidates in high-throughput screening platforms.
Detailed Parameters
| Product Name | Angiotensin A | CAS NO. | 34273-12-6 |
|---|---|---|---|
| Appearance | White to off-white lyophilized powder | Molecular Formula | C56H78N16O13 |
| Molecular Weight | 1183.34 g/mol | Purity (RP-HPLC) | ≥99.0% |
| Solubility | Water, dilute acetic acid, or PBS (pH 7.4) | Endotoxin | ≤0.5 EU/mg |
| Storage Conditions | Store at -20°C, dry and dark | Stock Location | USA |
Key Advantages
Ultra-High Purity
Guaranteed purity of ≥99.0% via RP-HPLC, ensuring consistent and reproducible results in sensitive biochemical assays.
Rapid Conversion
Optimized as a benchmark substrate for ACE, allowing rapid and complete conversion to Angiotensin II in vitro.
GMP Compliance
Produced by partners utilizing GMP-compliant systems with full batch traceability and standardized QC processes.
RAAS Modeling
Reliably replicates hypertensive states in animal models for testing cardiovascular and renal interventions.
Low Endotoxin
Strictly controlled endotoxin levels (≤0.5 EU/mg), making it ideal for cell-based studies and signal transduction profiles.
Full Documentation
Each batch is accompanied by a COA, HPLC purity report, and MS chromatograms for absolute transparency.
Product Gallery
Management Platforms
Quality Control
Rigorous HPLC and Mass Spectrometry validation for every production batch.
GMP Production
Strict adherence to GMP and FDA standards in our synthesis and purification labs.
Batch Traceability
Complete documentation from raw material procurement to final lyophilization.
Stability Monitoring
Continuous monitoring of storage conditions at -20°C to ensure long-term potency.
Global Logistics
Secure air freight via DHL/FedEx with specialized temperature-controlled packaging.
Technical Support
Professional guidance on solubility and reconstitution for diverse research needs.
Investment Return Comparison
| Evaluation Metric | Standard Grade | GlobalTech High-Purity |
|---|---|---|
| Purity Level | 95% - 98% | ≥99.0% (Certified) |
| Batch Consistency | Moderate Variation | High Stability (COA Provided) |
| Conversion Efficiency | Variable Rates | Optimized Michaelis-Menten Km |
| Endotoxin Level | Unspecified | ≤0.5 EU/mg |
| Research Reliability | Basic Screening | Pharmaceutical-Grade Validation |
Frequently Asked Questions
It is primarily used as a substrate for ACE activity assays, allowing researchers to evaluate the inhibitory potency of ACE inhibitor drugs and study the RAAS cardiovascular pathways.
It must be stored at -20°C in a dry, dark, and well-sealed container. It is critical to avoid repeated freeze-thaw cycles to prevent peptide degradation.
No, Angiotensin A is strictly designated for laboratory research, drug discovery, and biochemical assays. It is not a clinical therapeutic agent.
The product is soluble in water, dilute acetic acid, or Phosphate Buffered Saline (PBS) at pH 7.4. It is insoluble in common organic solvents like ethanol or methanol.
Each batch comes with a complete Certificate of Analysis (COA), RP-HPLC purity reports, and Mass Spectrometry (MS) chromatograms to verify identity and purity.
Yes, it is frequently used in preclinical animal studies to induce experimental hypertension by replicating the overactivation of the RAAS system.
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