Histone H3 (1 – 25),amide
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Histone H3 (1 - 25),amide |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C110H202N42O32 |
| Molecular Weight | 2625.1g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, dilute acetic acid, PBS (pH 7‑8) |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | The N-terminal segment (positions 1-25) of histone H3 is C-terminusally amidated. This region contains multiple lysine residues and can be modified by acetylation, methylation, and other processes, participating in the regulation of chromatin structure and gene expression. It is commonly used in epigenetic modification, antibody production, and protein-protein interaction studies. |
| Storage Conditions | Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Histone H3 (1-25), amide functions as a biologically active fragment of the core histone H3, which is integral to nucleosome structure and chromatin organization. The N-terminal tail of histone H3 protrudes from the nucleosome and serves as a platform for dynamic post-translational modifications (PTMs). These PTMs—such as acetylation, methylation, and phosphorylation—create a "histone code" that regulates DNA accessibility, transcription factor recruitment, and gene expression. Specifically, this peptide can be used as a substrate for histone acetyltransferases (HATs), methyltransferases, kinases, and deacetylases in vitro assays. It also serves as an antigen for generating antibodies targeting specific histone modifications, enabling detection and quantification of epigenetic marks in cellular and clinical samples.
2.PRODUCT INDICATIONS
3.CLINICAL EFFICACY OF PRODUCT
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
