Histone H3 (116–136), N15–39
Histone H3 (116–136), N15–39
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Histone H3 (116–136), N15–39 |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C112H197N39O30 |
| Molecular Weight | 2570.06g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, dilute Tris-HCl (pH 7.5-8.0), 0.1% TFA aqueous solution; moderately soluble in DMSO |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Site-specific modified 21-mer fragment of human Histone H3 (116-136) with N15-39 modification. |
| Storage Conditions | Store at -20°C to -80°C in a sealed, dry and light-protected container; avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This peptide does not have an intrinsic biological activity in isolation. Its function is defined by its role as a specific substrate or binding target for chromatin-associated proteins and enzymes. As part of the native histone H3 tail in vivo, this region protrudes from the nucleosome and is a hotspot for dynamic PTMs that regulate chromatin structure and gene expression.
2.PRODUCT INDICATIONS
- Enzyme Activity Assays: Serving as a substrate in in vitrohistone methyltransferase (HMT) or demethylase (KDM) activity assays, often using radioactive (³H-SAM) or antibody-based detection to measure modification levels.
- Epitope Mapping & Antibody Validation: Used as a critical control antigen to test the specificity of commercial or custom antibodies against H3 modifications (methylation, acetylation) within this sequence via dot blot, peptide array, or competitive binding assays.
- Interaction Studies: Employed in pull-down assays, isothermal titration calorimetry (ITC), or surface plasmon resonance (SPR) to study the binding affinity and specificity of chromatin "reader" proteins for specific modification states on this H3 tail region.
- Chromatin Biochemistry: Investigating the biochemical consequences of specific modifications in this region on nucleosome stability, higher-order chromatin folding, or recruitment of effector complexes in reconstituted systems.
3.CLINICAL EFFICACY OF PRODUCT
- Research Tool Efficacy: Its efficacy is defined by its performance as a pure, well-defined substrate that enables precise measurement of enzyme activity and antibody specificity, generating reliable and reproducible epigenetic data.
- Disease Relevance & Target Validation: The specific modifications on this H3 region (e.g., H3K122me, H3K128me) are implicated in gene regulation, DNA repair, and cancer. Aberrant activity of the enzymes that modify these sites (e.g., NSD2/MMSET in multiple myeloma) are validated therapeutic targets.
- Drug Discovery Enabler: This peptide is used in high-throughput screening (HTS) campaigns to identify and characterize small-molecule inhibitors of histone methyltransferases or demethylases that are drivers of cancers and other diseases.
- Diagnostic Development: Antibodies validated using this peptide are essential reagents for diagnostic assays that detect specific histone modification patterns in tumor samples (e.g., by immunohistochemistry), which can have prognostic value.
- Clinical Connection: While the peptide is not a drug, the enzymes and modifications it helps study are targeted by drugs in development (e.g., EZH2 inhibitors, LSD1 inhibitors). This tool is foundational to that preclinical research.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
May 25, 26
Premium API Oxandrolone Ucinky Manufacturing
Premium API Oxandrolone Ucinky Manufacturing Leading global supplier of high-purity chemical raw materials for pharmaceutical grade Oxandrolone Ucinky, combining precision engineering with industrial scale. 5000 kg Annual Output 120 Countries Served 5 Days Sample Lead Time 99.7 On-Time Delivery Industrial Precision Pure Chemical Synthesis Engineering the future of pharmaceutical intermediates with unmatched stability. Our facility stands as a global leader in the oxandrolone ucinky sector, utilizing CRYOGENIC CRYSTALLIZATION and advanced chromatography to ensure an assay purity exceeding 99.8. We integrate a fully automated closed-loop system that eliminates human error and contamination.
May 22, 26
Clinical Benefits and Applications of Oxandrolone Therapy
Oxandrolone therapy represents a sophisticated intersection of endocrine science and regenerative medicine, primarily utilized to address muscle wasting and metabolic dysfunction. In the global pharmaceutical landscape, this specific approach to androgen therapy is valued for its unique ability to promote protein synthesis while exhibiting a lower androgenic profile compared to traditional steroids, making it a critical tool for patients recovering from severe trauma or chronic illness. From a clinical perspective, understanding the nuances of oxandrolone therapy is essential for optimizing patient outcomes in weight gain and tissue repair.
May 20, 26
Clinical Benefits and Production of Oxandrolone Steroid
The global pharmaceutical landscape has seen a significant rise in the demand for highly specialized anabolic agents, among which the oxandrolone steroid stands out due to its unique chemical profile and therapeutic versatility. As a modified version of dihydrotestosterone, this compound provides a potent means of addressing muscle wasting and metabolic deficits, making it a critical asset in both clinical rehabilitation and advanced physiological research. Understanding the nuances of this synthetic compound is essential for healthcare providers and researchers alike, as it balances efficacy with a relatively lower androgenic profile compared to other steroids.
