Name: HO-STE-GLU(AEEA-AEEA-OSU)-OH High-Purity Peptide Compound
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HO-STE-GLU(AEEA-AEEA-OSU)-OH CAS NO.1169630-40-3

HO-STE-GLU(AEEA-AEEA-OSU)-OH CAS NO.1169630-40-3

HO-STE-GLU(AEEA-AEEA-OSu)-OH is a key intermediate in peptide synthesis, featuring a stearic acid-glutamic acid backbone with dual AEEA spacers and an active OSu ester. It enables efficient conjugation to amines, enhancing molecular solubility and stability.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	HO-STE-GLU(AEEA-AEEA-OSU)-OH
CAS NO.	1169630-40-3
Appearance	White to off-white lyophilized powder or amorphous solid.
Molecular Formula	C₄₉H₉₀N₄O₁₄
Molecular Weight	681.80 g/mol
Amino Acid Sequence	H-Ste-Glu(AEEA-AEEA-OSU)-OH
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in DMSO (≥ 20 mg/mL) Soluble in methanol and ethanol (≥ 5 mg/mL) Slightly soluble in water (≤ 1 mg/mL) Note: Sonication and gentle heating can improve dissolution.
Endotoxin	< 1.0 EU/mg
Biological Activity	This compound is a lipid-modified peptide derivative designed for use in peptide-drug conjugation (PDC) and targeted drug delivery systems.
Storage Conditions	Short-term (≤ 1 month): Store at 2–8°C in a sealed container, protected from light and moisture. Long-term (≥ 3 months): Store at -20°C or below in a desiccated environment, avoiding repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	10g

1.MECHANISM OF ACTION

This reagent acts as a versatile chemical linker, bridging hydrophilic bioactive molecules with hydrophobic lipid anchors via its functional groups. The stearyl lipid chain (HO-STE) provides strong hydrophobic interaction with cell membranes, facilitating cellular internalization and anchoring. The glutamic acid linker offers an additional carboxylic acid site for potential further modifications or direct coupling.

2.PRODUCT INDICATIONS

Lipidated Vaccine Development – Conjugation of antigens to lipid carriers for enhanced immune response.

Antibody-Drug Conjugates (ADCs) – Linking cytotoxic payloads to antibodies via PEG-lipid spacers for targeted cancer therapy.

Cell-Penetrating Peptide Conjugates – Enhancing membrane permeability of therapeutic peptides and oligonucleotides.

Nanocarrier Functionalization – Surface modification of liposomes and lipid nanoparticles for targeted delivery.

Diagnostic Imaging Probes – Conjugation of imaging agents to lipid carriers for improved biodistribution and targeting.

3.CLINICAL EFFICACY OF PRODUCT

As a conjugation reagent, HO-STE-GLU(AEEA-AEEA-OSU)-OH does not have direct therapeutic efficacy itself, but it is instrumental in creating conjugates with enhanced clinical performance. Lipid-PEG conjugates produced using this linker demonstrate markedly improved pharmacokinetic profiles—including prolonged circulation half-life, enhanced target tissue accumulation, and reduced off-target toxicity.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.

Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.