Icatibant acetate CAS NO.130308-48-4/138614-30-9
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Icatibant acetate |
| CAS NO. | 130308-48-4/138614-30-9 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C59H89N19O13S |
| Molecular Weight | 1304.54 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Freely soluble in water; sparingly soluble in methanol |
| Endotoxin | ≤5 EU/mg |
| Biological Activity | Potent and selective bradykinin B2 receptor antagonist |
| Storage Conditions | Store at 2–8°C, protected from light; do not freeze |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The therapeutic effect of Icatibant acetate is mediated through its highly selective blockade of the bradykinin B2 receptor, effectively competing with and displacing the endogenous ligand bradykinin. In HAE, dysregulation of the kallikrein-kinin system leads to excessive bradykinin production, which causes vasodilation and a dramatic increase in vascular permeability, resulting in angioedema. By antagonizing the B2 receptor, Icatibant directly interrupts this pathological signaling cascade at the receptor level, thereby reducing edema formation and alleviating the painful swelling associated with acute HAE attacks.
2.PRODUCT INDICATIONS
Icatibant acetate is explicitly indicated for the treatment of acute attacks of hereditary angioedema (HAE) in adults, adolescents, and children aged 2 years and older. It is suitable for managing swelling across various anatomical locations, including the abdomen, face, extremities, and critically, the larynx (throat), where rapid intervention is vital to prevent life-threatening airway obstruction. The product is intended for on-demand, as-needed use during an active attack and is not designed for routine prophylaxis. It is essential that patients with laryngeal symptoms seek immediate medical attention even after self-administering the drug.
3.CLINICAL EFFICACY OF PRODUCT
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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