Isoliensinine CAS NO.6817-41-0
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Isoliensinine |
| CAS NO. | 6817-41-0 |
| Appearance | White to off-white powder |
| Molecular Formula | C₃₇H₄₂N₂O₆ |
| Molecular Weight | 610.74 g/mol |
| Amino Acid Sequence | β-Ala-His |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in DMSO, ethanol, chloroform, and dichloromethane; slightly soluble in water; sonication recommended to improve dissolution |
| Endotoxin | <0.1 EU/mg |
| Biological Activity | Exhibits antioxidant, anti-inflammatory, anti-cancer (induces apoptosis in triple-negative breast cancer cells), anti-fibrotic, and anti-arrhythmic activities |
| Storage Conditions | Store at 2-8°C, protected from light and moisture. |
| Stock Location | Stock in USA |
| MOQ | 10g |
1.MECHANISM OF ACTION
Isoliensinine exerts its biological effects through multiple, often synergistic pathways. A core mechanism involves the induction of autophagy and apoptosis in cancer cells, frequently mediated by the inhibition of the PI3K/Akt/mTOR signaling pathway. It also demonstrates potent anti-fibrotic activity by suppressing the TGF-β1/Smad signaling cascade, thereby inhibiting the activation and proliferation of fibroblasts. Furthermore, it exhibits anti-inflammatory effects by downregulating NF-κB and MAPK pathways, and protects cardiac cells by modulating ion channels and reducing oxidative stress.
2.PRODUCT INDICATIONS
Isoliensinine is indicated for use in advanced pharmacological and biomedical research. Its primary applications are as a lead compound in anti-cancer drug discovery (particularly for breast, liver, and lung cancers), and in studies of cardiac arrhythmia and myocardial protection. It is also utilized in research on anti-fibrotic therapies for liver, lung, and renal fibrosis, as well as in neuropharmacology for its potential neuroprotective effects. It serves as a high-purity reference standard for the quality control of lotus seed embryo extracts.
3.CLINICAL EFFICACY OF PRODUCT
Extensive preclinical studies have established the strong efficacy profile of Isoliensinine. In various cancer models, it has been shown to inhibit tumor growth and metastasis, enhance the sensitivity of cancer cells to chemotherapy, and prolong survival in animal studies. In cardiovascular models, it effectively reduces the incidence of arrhythmias and protects against ischemia-reperfusion injury. Anti-fibrotic studies demonstrate its ability to significantly reduce collagen deposition and improve organ function in models of hepatic and pulmonary fibrosis. These results position it as a promising candidate for clinical translation.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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