isookanin CAS NO.1036-49-3
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Isookanin |
| CAS NO. | 1036-49-3 |
| Appearance | Yellowish-brown to light yellow powder (for reference standard grade) |
| Molecular Formula | C₁₅H₁₂O₆ |
| Molecular Weight | 288.25 g/mol |
| Purity (RP-HPLC) | ≥95% |
| Solubility | Soluble in DMSO (≥100 mg/mL), chloroform, dichloromethane, ethyl acetate, acetone; sparingly soluble in water |
| Endotoxin | <0.05 EU/mg |
| Biological Activity | - Antiviral activity against HSV and VZV- Antioxidant activity (DPPH radical-scavenging, IC₅₀ = 7.9 ± 0.53 μM)- α-amylase inhibitory activity (IC₅₀ = 0.447 mg/mL)- Anti-diabetic and anti-inflammatory potential |
| Storage Conditions | -20°C (long-term, dry, sealed, protected from light); 2-8°C (short-term, ≤3 months) |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Isookanin exerts its biological effects primarily through the modulation of key cellular signaling pathways involved in inflammation and oxidative stress. It has been shown to inhibit the production of pro-inflammatory mediators, such as nitric oxide (NO), prostaglandin E2 (PGE2), and cytokines (e.g., TNF-α, IL-6), by suppressing the activation of the NF-κB and MAPK pathways. Additionally, it enhances cellular antioxidant defenses, potentially through the upregulation of the Nrf2 pathway, leading to increased expression of protective enzymes like heme oxygenase-1 (HO-1).
2.PRODUCT INDICATIONS
Isookanin is indicated for use in scientific research as a reference standard for the quality control of plant extracts containing this flavanone. Its primary applications are in pharmacological studies investigating anti-inflammatory, antioxidant, and hepatoprotective agents. It serves as a lead compound in the development of potential nutraceuticals for managing inflammatory conditions, supporting liver health, and combating oxidative stress-related cellular damage.
3.CLINICAL EFFICACY OF PRODUCT
While direct human clinical data on Isookanin is limited, robust preclinical studies demonstrate its promising efficacy. In vitro and in vivo models have shown that Isookanin effectively reduces inflammation in macrophage and animal models, protects liver cells against toxin-induced damage (hepatoprotection), and exhibits significant free radical scavenging activity. These results provide a strong foundation for its potential therapeutic use, warranting further investigation into its bioavailability and specific clinical applications.
- 4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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