KPV CAS NO.67727-97-3
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | KPV |
| CAS NO. | 67727-97-3 |
| Appearance | White to off-white powder, free-flowing, no visible impurities |
| Molecular Formula | C16H30N4O4 |
| Molecular Weight | 342.43 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water, dilute acetic acid, and common aqueous buffers (e.g., PBS); slightly soluble in methanol |
| Endotoxin | ≤ 0.1 EU/mg |
| Biological Activity | Exhibits potent anti-inflammatory, immunomodulatory, and tissue-repair properties; modulates NF-κB and cytokine signaling pathways |
| Storage Conditions | Store at 2–8°C, protected from light and moisture; stable for ≥24 months under recommended conditions |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
KPV exerts its effects primarily by inhibiting the nuclear factor-kappa B (NF-κB) signaling pathway, thereby preventing the nuclear translocation of pro-inflammatory transcription factors and the subsequent release of cytokines such as TNF-α, IL-6, and IL-1β. It achieves this through a unique melanocortin receptor-independent mechanism involving cellular uptake via the PepT1 transporter, which is upregulated in inflamed tissues, allowing for targeted accumulation and suppression of MAPK signaling cascades to restore cellular homeostasis.
2.PRODUCT INDICATIONS
This product is indicated for in-vitro and pre-clinical research applications investigating conditions characterized by dysregulated inflammation and epithelial damage, including inflammatory bowel disease (IBD) models such as colitis, dermal inflammation studies like psoriasis and atopic dermatitis, and experimental protocols for mucosal wound healing and immune system modulation in autoimmune research settings.
3.CLINICAL EFFICACY OF PRODUCT
In experimental models, KPV has demonstrated significant efficacy in reducing disease activity indices, colonic shortening, and myeloperoxidase levels in murine colitis, while also accelerating re-epithelialization and reducing inflammatory infiltrates in dermal wound models. Research indicates that KPV can restore tight junction protein expression to enhance gut barrier function and shift macrophage polarization towards an anti-inflammatory M2 phenotype, supporting its potential as a research-grade therapeutic candidate for inflammatory pathologies.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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