Larazotide CAS NO. 258818-34-7
Larazotide CAS NO. 258818-34-7
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Larazotide |
| CAS NO. | 258818-34-7 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C32H55N9O10 |
| Molecular Weight | 725.83 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water and certain organic solvents such as DMSO at appropriate concentrations |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Larazotide is a synthetic peptide that acts as an intestinal permeability modulator. It has been shown to inhibit the paracellular pathway in the intestinal epithelium, reducing the passage of harmful substances from the gut lumen into the underlying tissues. In preclinical and clinical studies, it has demonstrated efficacy in improving symptoms associated with various gastrointestinal disorders, such as irritable bowel syndrome and inflammatory bowel diseases, by restoring normal intestinal barrier function. |
| Storage Conditions | Store at – 20°C in a dry and dark place. Protect from light, moisture, and extreme temperatures to maintain product stability. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Larazotide (AT-1001) is a synthetic octapeptide that functions as a tight junction regulator by binding to the zonulin receptor. This binding inhibits zonulin-mediated disassembly of intestinal epithelial tight junctions, thereby reducing paracellular permeability. By preserving barrier integrity, Larazotide helps prevent translocation of harmful substances such as gluten peptides and bacterial toxins across the gut mucosa. This mechanism is believed to modulate immune activation in the intestine and reduce symptoms associated with intestinal permeability-related disorders.
2.PRODUCT INDICATIONS
Primary Therapeutic Target:
Treatment of celiac disease and non-celiac gluten sensitivity by maintaining intestinal barrier function and reducing gluten-induced immune responses.
Gastrointestinal Applications:
Adjunctive therapy for leaky gut syndrome and inflammatory bowel disease (IBD) where increased intestinal permeability is implicated.
Investigational use in preventing symptom flare-ups triggered by gluten exposure in susceptible individuals.
Research Applications:
Studies on tight junction regulation, zonulin biology, and gut barrier function.
Comparative efficacy research with other barrier-enhancing agents and immunomodulators.
3.CLINICAL EFFICACY OF PRODUCT
Barrier Function: Lowers intestinal permeability markers in gluten-exposed celiac patients.
Symptom Control: Reduces GI/extraintestinal symptoms; improves quality of life.
Onset: Effects seen within days to weeks.
Safety: Generally well-tolerated; mild transient GI discomfort; no serious systemic adverse events.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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