[Leu³¹,Pro³⁴]-Neuropeptide Y (13-36) (human, rat) CAS NO.302798-54-5

[Leu³¹,Pro³⁴]-Neuropeptide Y (13-36) (human, rat) CAS NO.302798-54-5

[Leu³¹,Pro³⁴]-Neuropeptide Y (13-36) (human, rat) CAS NO.302798-54-5

[Leu³¹,Pro³⁴]-Neuropeptide Y (13-36) (human, rat) CAS NO.302798-54-5

[Leu³¹,Pro³⁴]-Neuropeptide Y (13-36) (human, rat) CAS NO.302798-54-5

[Leu³¹,Pro³⁴]-Neuropeptide Y (13-36) (human, rat) (CAS 302798-54-5) is a premium modified NPY fragment with a defined molecular formula (C₁₃₄H₂₀₆N₄₀O₃₅S) and molecular weight (2969.45 g/mol). As a professional NPY fragment supplier, we deliver this product with ≥98% purity (RP-HPLC), low endotoxins, and Y1 receptor-specific activity, tailored for neuroscience research and pharmaceutical R&D. It excels as a selective Y1 receptor agonist, widely used in appetite regulation, metabolic research, and cardiovascular studies. Choose our product for high-quality support in your receptor-specific research!



TECHNICAL SPECIFICATIONS


Item
Specification
Product Name
[Leu³¹,Pro³⁴]-Neuropeptide Y (13-36) (human, rat)
CAS NO.
302798-54-5
Appearance
White to off-white lyophilized powder
Molecular Formula
C₁₃₄H₂₀₆N₄₀O₃₅S
Molecular Weight
2969.45g/mol 
Purity (RP-HPLC)
≥ 95.0%
Solubility

Soluble in water (≥1 mg/mL), PBS buffer (pH 7.2–7.4), and DMSO; slightly soluble in methanol/ethanol

Endotoxin< 1.0 EU/mg
Biological Activity
Selective agonist of neuropeptide Y Y1 receptors; modulates appetite, energy metabolism, and cardiovascular function; exhibits enhanced receptor selectivity and stability compared to native NPY fragments
Storage Conditions
-20°C for long-term storage (stable for 2 years); avoid repeated freeze-thaw cycles; store desiccated
Stock Location
Stock in USA
MOQ
1g


1.MECHANISM OF ACTION

The biological effects of [Leu³¹,Pro³⁴]-Neuropeptide Y (13-36) are mediated through its high-affinity and selective binding to neuropeptide Y Y1 receptors, a subtype of G-protein-coupled receptors (GPCRs) primarily distributed in the central nervous system, vascular smooth muscle, and peripheral tissues. The Leu³¹ and Pro³⁴ substitutions optimize the peptide’s conformational structure, enhancing its binding affinity for Y1 receptors while reducing cross-reactivity with other NPY receptor subtypes (Y2, Y4, Y5).


2.PRODUCT INDICATIONS

NPY Y1 receptor research: Investigation of Y1 receptor structure-function relationships, serving as a standard ligand for receptor activation assays, agonist/antagonist screening, and selectivity validation.

Neuroscience research: Study of Y1 receptor-mediated appetite regulation, energy metabolism, mood, and stress response pathways in human and rat models.

Cardiovascular research: Evaluation of Y1 receptor-dependent vasoconstriction and blood pressure modulation, supporting studies on NPY-related cardiovascular pathologies.



3.CLINICAL EFFICACY OF PRODUCT

[Leu³¹,Pro³⁴]-Neuropeptide Y (13-36) (CAS 302798-54-5) is widely used in preclinical research, with proven efficacy in human and rat in vitro and in vivo models. In rodent studies, it has shown significant Y1 receptor-specific appetite-stimulating effects, providing a reliable tool for dissecting the role of Y1 receptors in obesity and energy metabolism disorders without off-target effects from other NPY receptors.


4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.


Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.


We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards


Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.


5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.


We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.


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If you have any product requirements, please send an email to:sales@huanqiukeji9.com;whatsapp:85244219157

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