Name: High-Purity Leu31,Pro34-Neuropeptide Y for Research Use
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[Leu31,Pro34]-Neuropeptide Y (human, rat) CAS NO.132699-73-1

[Leu³¹,Pro³⁴]-Neuropeptide Y (human, rat) (CAS NO. 132699-73-1) is a synthetic, site-specifically modified analog of the endogenous neuropeptide Y (NPY). This research-grade peptide features two key amino acid substitutions: leucine at position 31 and proline at position 34. These modifications are engineered to selectively alter its receptor binding profile, transforming it into a potent and Y1 receptor-preferring agonist, making it a vital tool for dissecting NPY receptor subtype-specific functions.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Leu³¹,Pro³⁴]-Neuropeptide Y (human, rat)
CAS NO.	132699-73-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C190H286N54O56
Molecular Weight	4222.7/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥1 mg/mL), 0.1% TFA in aqueous solution, dilute acetic acid & dimethyl sulfoxide
Endotoxin	≤1.0 EU/mg
Biological Activity	widely used for Y1 receptor targeted neuroscience and metabolic research.
Storage Conditions	Store at ≤ -20°C in a dry, dark, sealed container.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This analog functions as a potent and selective agonist for the Neuropeptide Y Y1 receptor (NPY Y1R). The substitution of proline at position 34 significantly enhances its selectivity for Y1R over other NPY receptor subtypes (particularly Y2 and Y5). Upon binding to Y1R, it activates the associated Gi/o protein, leading to inhibition of adenylate cyclase and a decrease in intracellular cyclic adenosine monophosphate (cAMP) levels.

2.PRODUCT INDICATIONS

This product is indicated for advanced research in cardiovascular biology, neuropharmacology, and metabolic studies. Key applications include: selectively activating Y1 receptors to study their specific roles in vasoconstriction and blood pressure regulation, investigating Y1-mediated effects on feeding behavior, obesity, and energy homeostasis, exploring Y1 receptor functions in anxiety, stress, and emotional behavior, and serving as a reference Y1-selective agonist in receptor binding and functional assays (e.g., cAMP inhibition, calcium mobilization) to characterize novel ligands.

3.CLINICAL EFFICACY OF PRODUCT

[Leu³¹,Pro³⁴]-NPY is a fundamental research probe, not a clinical drug. Its efficacy is defined by its unparalleled utility as a selective pharmacological tool. Research utilizing this analog has been critical in delineating the distinct physiological and pathophysiological roles of the Y1 receptor, separate from other NPY receptors.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

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