Name: Licochalcone B CAS 58749-23-8 - Natural Anti-Inflammatory Agent
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Licochalcone B CAS NO.58749-23-8

Licochalcone B is a naturally occurring chalcone compound primarily isolated from the roots of Glycyrrhiza inflataand related licorice species, renowned for its diverse pharmacological properties including antioxidant, anti-inflammatory, and anticancer effects. This compound is widely utilized in biomedical research to investigate cellular signaling pathways, particularly those involved in inflammation and tumorigenesis, making it an essential tool for researchers studying chronic diseases and drug discovery. It exhibits strong inhibitory effects on pro-inflammatory cytokines and has shown potential in suppressing cancer cell proliferation across various in vitro and in vivo models, offering a valuable natural scaffold for therapeutic development.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Licochalcone B
CAS NO.	58749-23-8
Appearance	Yellow to yellow-brown amorphous powder
Molecular Formula	C₁₆H₁₄O₅
Molecular Weight	286.28 g/mol
Amino Acid Sequence	Not applicable (Natural compound)
Purity (RP-HPLC)	≥98.0%
Solubility	Soluble in DMSO, methanol, ethanol; slightly soluble in water
Endotoxin	< 1 EU/mg (for solution)
Biological Activity	Potent antioxidant, anti-inflammatory, anticancer, and antibacterial activities; inhibits NF-κB and STAT3 signaling pathways
Storage Conditions	Store at -20°C, protected from light and moisture
Stock Location	USA / Germany / China (optional, based on actual stock)
MOQ	1 mg

1.Mechanism of Action

Licochalcone B exerts its biological effects primarily through the modulation of key intracellular signaling pathways, notably by inhibiting the activation of nuclear factor-kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3), which are critical regulators of inflammation, cell survival, and proliferation. Additionally, it scavenges reactive oxygen species (ROS) and induces mitochondrial-mediated apoptosis in cancer cells by upregulating pro-apoptotic proteins such as Bax and downregulating anti-apoptotic Bcl-2. Its ability to disrupt microtubule assembly and inhibit topoisomerase II also contributes to its cytotoxic effects against tumor cells, while its anti-inflammatory action is further enhanced by suppressing cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression.

2.Product Indications

This compound is indicated for use in preclinical research focused on oncology, immunology, and inflammatory diseases, serving as a lead compound for drug development targeting cancer, arthritis, and neurodegenerative disorders. It is suitable for in vitro and in vivo studies exploring its potential as an adjunctive therapeutic agent in chemotherapy-resistant cancers and chronic inflammatory conditions. Researchers studying natural product chemistry, herbal medicine, and molecular pharmacology will find Licochalcone B invaluable for elucidating mechanisms of action and validating biological targets in disease models.

3.Clinical Efficacy of Product

While Licochalcone B is primarily a research chemical and not yet approved for clinical use, extensive preclinical studies have demonstrated its efficacy in reducing tumor growth, suppressing metastasis, and alleviating inflammation in animal models. In cancer research, it has shown synergistic effects with conventional chemotherapeutics, enhancing cytotoxicity while reducing side effects. Its ability to penetrate the blood-brain barrier and modulate neuroinflammatory responses suggests potential for treating neurological disorders. Although clinical trials are still pending, the robust in vitro and in vivo data support its progression into early-phase human studies, particularly for cancers with high unmet medical needs.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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