LL-37(human) CAS NO.597562-32-8
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | LL-37(human) |
| CAS NO. | 597562-32-8 |
| Appearance | White lyophilized powder |
| Molecular Formula | C205H340N60O53 |
| Molecular Weight | 4493.31 |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water, PBS, and dilute acetic acid |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Antimicrobial, immunomodulatory, and wound-healing promoting activity in vitro and in vivo |
| Storage Conditions | Store at -20°C, protected from light; avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide exerts its effects through a multi-pronged mechanism, initially utilizing its cationic charge to electrostatically interact with and disrupt the negatively charged membranes of bacteria, fungi, and enveloped viruses, leading to cell lysis. Beyond direct microbial killing, LL-37 binds to host cell receptors such as FPRL1 and P2X7, modulating immune responses by recruiting neutrophils and monocytes to infection sites while simultaneously neutralizing bacterial endotoxins (LPS) to prevent septic shock. It also promotes tissue regeneration by activating EGFR and MAPK signaling pathways to stimulate keratinocyte migration and angiogenesis.
2.PRODUCT INDICATIONS
This product is indicated for scientific research applications focusing on antimicrobial resistance, immunology, and dermatology. It is particularly relevant for studies involving chronic non-healing wounds, diabetic ulcers, and burn injuries where microbial biofilms impede recovery. Researchers investigating inflammatory skin conditions like psoriasis and rosacea, as well as those exploring novel therapies for multidrug-resistant bacterial infections (including MRSA) and viral infections such as influenza and SARS-CoV-2, are the primary target users for this investigational reagent.
3.CLINICAL EFFICACY OF PRODUCT
In preclinical and translational models, LL-37 has demonstrated significant efficacy in accelerating wound closure rates by up to 40% compared to controls, effectively reducing bacterial load in infected wounds and disrupting established biofilms. Clinical trial data from topical formulations have shown improved re-epithelialization in venous leg ulcers and reduced infection rates in burn patients. Its immunomodulatory properties have been validated in reducing excessive inflammation in sepsis models while enhancing clearance of respiratory pathogens, positioning it as a promising candidate for adjunctive therapy in complex infections.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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