Name: Magainin I CAS 108433-99-4: Antimicrobial Peptide Supplier
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Magainin I CAS NO.108433-99-4

Magainin I is a naturally derived antimicrobial peptide (AMP) originally isolated from the skin of the African clawed frog (Xenopus laevis). It is a cationic, amphipathic peptide renowned for its broad-spectrum activity against bacteria, fungi, and viruses. This research-grade peptide is characterized by its unique ability to selectively target microbial membranes while exhibiting low cytotoxicity to mammalian cells, making it a pivotal tool for studying novel anti-infective strategies and innate immunity mechanisms.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Magainin I
CAS NO.	108433-99-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₄₁H₂₂₄N₄₆O₁₉S₃
Molecular Weight	3095.7 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, acidic solutions; insoluble or poorly soluble in neutral buffers
Endotoxin	< 0.1 EU/mg (by LAL assay)
Biological Activity	Antimicrobial, anticancer, and immunomodulatory activities demonstrated in vitro and in vivo studies
Storage Conditions	Store at -20°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide exerts its antimicrobial effects primarily through a membrane-disruptive mechanism. Upon encountering microbial cells, Magainin I adopts an amphipathic α-helical structure that electrostatically interacts with negatively charged phospholipids abundant in bacterial membranes. This interaction leads to the formation of transient pores or toroidal defects in the lipid bilayer, causing rapid depolarization, ion leakage, and ultimately osmotic cell lysis without requiring specific receptor binding, thereby minimizing the development of microbial resistance.

2.PRODUCT INDICATIONS

Magainin I is indicated for in vitro and in vivo research applications focused on combating multidrug-resistant pathogens, biofilm disruption, and immunomodulation. It serves as a critical reagent for microbiologists and pharmaceutical R&D teams developing next-generation antibiotics, antimicrobial coatings for medical devices, and therapeutic agents targeting Gram-positive and Gram-negative infections, including Staphylococcus aureusand Escherichia coli.

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3.CLINICAL EFFICACY OF PRODUCT

Preclinical studies demonstrate that Magainin I and its synthetic analogs exhibit potent bactericidal activity at low micromolar concentrations, effectively reducing bacterial load in systemic infection models. It has shown promising efficacy in topical formulations for impetigo and wound healing applications, with ongoing research highlighting its potential as an adjuvant therapy to enhance the effectiveness of conventional antibiotics against persistent biofilms.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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If you have any product requirements, please send an email to:support@huanqiukeji9.com;whatsapp:85296236544