Mastoparan X CAS NO.72093-22-2

Mastoparan X CAS NO.72093-22-2

Mastoparan X  CAS NO.72093-22-2

Mastoparan X CAS NO.72093-22-2

Mastoparan X CAS NO.72093-22-2

Mastoparan X (CAS NO. 72093-22-2) is a synthetic, 14-amino acid amphipathic peptide toxin, originally derived from wasp venom. Known for its potent membrane-active and cell-penetrating properties, it is a high-purity research-grade reagent widely used as a direct G-protein activator and a model for studying membrane interactions and signal transduction pathways.



TECHNICAL SPECIFICATIONS


Item
Specification
Product Name
Mastoparan X
CAS NO.
72093-22-2
Appearance
White to off-white lyophilized powder
Molecular Formula
C73H126N20O15S
Molecular Weight
 1556.01g/mol 
Purity (RP-HPLC)
≥ 95.0%
Solubility

Soluble in water, 0.1 M acetic acid, or DMSO at a concentration ≥ 1 mg/mL.

Endotoxin< 1.0 EU/mg
Biological Activity
Potent activator of G-proteins; induces histamine release from mast cells; exhibits antimicrobial activity against Gram-positive and Gram-negative bacteria.
Storage Conditions
Store long-term at -20°C to -80°C; avoid repeated freeze-thaw cycles.
Stock Location
Stock in USA
MOQ
1g


1.MECHANISM OF ACTION

Mastoparan X functions primarily by directly binding to and activating heterotrimeric G-proteins (Gα subunits, particularly Gi/o), bypassing traditional receptor activation. It inserts into phospholipid membranes, forming pores or destabilizing bilayer integrity, which facilitates its cell-penetrating ability and leads to downstream effects such as phospholipase activation, calcium mobilization, and histamine release from mast cells.


2.PRODUCT INDICATIONS

This peptide is indicated for research applications in cell biology, pharmacology, and biochemistry. It is used as a tool compound for: studying G-protein coupled receptor (GPCR)-independent G-protein signaling, investigating mast cell degranulation, exploring mechanisms of antimicrobial and anticancer peptides, and as a model for membrane pore formation and peptide-lipid interactions.


3.CLINICAL EFFICACY OF PRODUCT

As a research tool, Mastoparan X itself is not used for direct clinical application. However, its profound biological activities make it a valuable prototype in preclinical studies. Research utilizing Mastoparan X has contributed significantly to the understanding of G-protein signaling, membrane permeabilization mechanisms, and the design of novel antimicrobial or cell-penetrating peptides with potential therapeutic applications.


4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods 
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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