MBP (1-11), human CAS NO.106128-98-7
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | MBP (1-11), human |
| CAS NO. | 106128-98-7 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C52H88N22O17 |
| Amino Acid Sequence | Ac‑Ala‑Ser‑Gln‑Lys‑Arg‑Pro‑Ser‑Gln‑Arg‑His‑His‑NH₂ (human MBP residues 1‑11; N‑terminal acetylated, C‑terminal amidated) |
| Molecular Weight | 1293.42g/mol |
| Purity (RP-HPLC) | ≥95% (typical for research peptides) |
| Solubility | Soluble in water, PBS, or dilute acetic acid solution |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Immunodominant epitope of myelin basic protein; used in multiple sclerosis (MS) research, T‑cell activation studies, and autoimmune disease modeling. |
| Storage Conditions | Store at –20°C, protected from light and moisture. For long‑term storage, recommend –80°C. |
| Stock Location | Stock in USA |
| MOQ | 1mg |
1.MECHANISM OF ACTION
This peptide acts as a target antigen for autoreactive T-cells. In experimental settings, it binds to major histocompatibility complex (MHC) class II molecules on antigen-presenting cells, thereby activating myelin-specific CD4+ T-cells. This process mimics the autoimmune response that leads to the demyelination of nerve fibers, a hallmark of multiple sclerosis.
2.PRODUCT INDICATIONS
MBP (1-11), human is primarily used in preclinical research to model multiple sclerosis, study T-cell mediated autoimmunity, and evaluate potential therapeutic interventions. It is also applied in immunological assays, epitope mapping, and the development of diagnostic tools for demyelinating diseases.
3.CLINICAL EFFICACY OF PRODUCT
In experimental autoimmune encephalomyelitis (EAE) models, administration of MBP (1-11), human or similar peptides can induce disease, validating its role in studying MS pathogenesis. While not a therapeutic, it is an indispensable tool for screening and developing immunomodulatory drugs and for understanding the immunological basis of neuroinflammation.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight
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