Melanocyte Associated Antigen gp100
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Melanocyte Associated Antigen gp100 (Melanoma Antigen gp100) |
| CAS NO. | |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C43H68N12O13 |
| Amino Acid Sequence | Customizable (common epitopes: e.g., gp100(209‑217): IMDQVPFSV; gp100(280‑288): YLEPGPVTA; or full‑length recombinant protein) |
| Molecular Weight | 961.09g/mol |
| Purity (RP-HPLC) | ≥95.0% (peptide) / ≥90% (recombinant protein, by SDS‑PAGE) |
| Solubility | Soluble in water, PBS, DMSO (for peptides), or sterile buffer (for protein) |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Melanoma‑associated antigen; HLA‑A*0201‑restricted epitopes used in T‑cell activation, immunotherapy research, and cancer vaccine development. |
| Storage Conditions | Store at –20°C (lyophilized) or –80°C (solution). Protect from light and repeated freeze‑thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1mg |
1.MECHANISM OF ACTION
Melanocyte Associated Antigen gp100 functions as a tumor-associated antigen that is processed and presented by HLA class I molecules, particularly HLA-A*0201. This presentation activates cytotoxic T lymphocytes (CTLs), which then recognize and target gp100-expressing melanoma cells, leading to tumor cell lysis and immune-mediated clearance.
2.PRODUCT INDICATIONS
This product is primarily used in melanoma immunotherapy research, including cancer vaccine development, adoptive T-cell therapy, and immune checkpoint studies. It is also applied in epitope mapping, T-cell activation assays, and preclinical models to evaluate anti-tumor immune responses.
3.CLINICAL EFFICACY OF PRODUCT
Clinical studies have demonstrated that gp100-based immunotherapies can induce antigen-specific T-cell responses and have shown potential in improving outcomes in melanoma patients, particularly when combined with immune checkpoint inhibitors. Its role as a target antigen in therapeutic cancer vaccines continues to be investigated in clinical trials.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
