NAD+
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Nicotinamide Adenine Dinucleotide (oxidized form, NAD+) |
| CAS NO. | 53-84-9 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₂₁H₂₇N₇O₁₄P₂ |
| Molecular Weight | 663.43 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water (typically 50-100 mg/mL, depending on batch and conditions); insoluble in DMSO and ethanol |
| Endotoxin | ≤ 0.1 EU/mg (or below detection limit, as applicable for research grade) |
| Biological Activity | Acts as a crucial redox coenzyme in cellular metabolism, facilitating electron transfer in oxidation-reduction reactions; involved in energy production (ATP synthesis), DNA repair, and cell survival signaling pathways |
| Storage Conditions | Store lyophilized powder at 2-8°C or -20°C, protected from light and moisture; once reconstituted, store at -80°C for up to 1 year |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
NAD+ primarily functions as a co-substrate for sirtuins, PARPs, and CD38 enzymes, facilitating vital cellular processes such as DNA repair, epigenetic regulation, and calcium signaling. It acts as a critical electron acceptor and donor in mitochondrial oxidative phosphorylation, driving ATP production, while also influencing circadian rhythms, immune function, and stress response pathways. As cellular NAD+ levels decline with age, its replenishment is seen as a key strategy to restore youthful cellular function and resilience.
2.PRODUCT INDICATIONS
This product is indicated for research into aging biology, neurodegenerative diseases, metabolic disorders, and cardiovascular health. It is a key tool for studying cellular senescence, mitochondrial dysfunction, and the molecular basis of longevity. Researchers utilize NAD+ in models of Alzheimer's disease, diabetes, and age-related decline to explore interventions aimed at boosting cellular NAD+ levels and enhancing resilience.
3.CLINICAL EFFICACY OF PRODUCT
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: NAD #NicotinamideAdenineDinucleotide #LongevityResearch #AntiAging #CellularHealth #Metabolism #SirtuinActivator #MitochondrialFunction
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What are the Functions of Nicotinamide Adenine Dinucleotide?
Nicotinamide adenine dinucleotide (NAD⁺) is a vital coenzyme found in all living cells and plays a central role in energy metabolism and cellular function. It exists in two forms—NAD⁺ (oxidized) and NADH (reduced)—and acts as a key carrier of electrons in metabolic reactions.
One of its primary functions is in energy production. NAD⁺ participates in cellular respiration, particularly in glycolysis, the Krebs cycle, and oxidative phosphorylation. During these processes, it helps convert nutrients such as glucose and fatty acids into ATP, the main energy currency of the cell.
NAD⁺ is also essential for DNA repair and cellular maintenance. It serves as a substrate for enzymes like PARPs (poly ADP-ribose polymerases), which are involved in repairing damaged DNA and maintaining genomic stability. This function is critical for preventing cellular aging and dysfunction.
Another important role of NAD⁺ is in regulating sirtuins, a group of proteins associated with aging, metabolism, and stress resistance. By activating sirtuins, NAD⁺ helps influence processes such as inflammation control, mitochondrial function, and cellular survival.
Additionally, NAD⁺ is involved in redox reactions, helping maintain the balance between oxidative and reductive states in cells, which is essential for overall metabolic health.
Overall, NAD⁺ is a fundamental molecule required for energy production, DNA repair, and cellular regulation, making it central to life and metabolic function.
What are the Different Forms of Nicotinamide Adenine Dinucleotide?
Nicotinamide adenine dinucleotide (NAD) exists in several important forms that play distinct roles in cellular metabolism and biological regulation.
The two primary forms are NAD⁺ (oxidized form) and NADH (reduced form). NAD⁺ is the active electron acceptor that participates in metabolic reactions, while NADH is the electron-rich form that carries energy to the mitochondrial electron transport chain. The continuous conversion between NAD⁺ and NADH is essential for energy production (ATP synthesis) and maintaining cellular redox balance.
Another related form is NADP⁺ (nicotinamide adenine dinucleotide phosphate) and its reduced counterpart NADPH. Although structurally similar to NAD, NADP is primarily involved in anabolic reactions, such as fatty acid synthesis and antioxidant defense. NADPH plays a critical role in protecting cells from oxidative stress by supporting glutathione regeneration and other detoxification systems.
In addition to these functional forms, NAD also exists in different biological pools within the cell, including cytosolic NAD, mitochondrial NAD, and nuclear NAD. Each pool supports specific cellular processes depending on the location. For example, mitochondrial NAD is heavily involved in ATP production, while nuclear NAD is important for DNA repair and gene regulation.
NAD can also be found in bound and free states, depending on whether it is attached to enzymes or freely circulating within the cell. This affects how quickly it can participate in metabolic reactions.
Overall, the different forms of NAD—NAD⁺/NADH and NADP⁺/NADPH, along with their compartmental distribution—work together to regulate energy metabolism, redox balance, and cellular health.
Nicotinamide Adenine Dinucleotide Uses
Nicotinamide adenine dinucleotide (NAD⁺) is a essential coenzyme found in all living cells, and it plays a central role in a wide range of biological and metabolic processes. Its primary use in the body is related to energy production, where it functions as a key electron carrier in cellular respiration. NAD⁺ participates in glycolysis, the citric acid cycle, and oxidative phosphorylation, helping convert nutrients such as glucose, fatty acids, and amino acids into ATP, the main energy source for cellular activity.
Another important use of NAD⁺ is in redox reactions, where it cycles between its oxidized form (NAD⁺) and reduced form (NADH). This conversion is essential for maintaining the balance of cellular metabolism and ensuring efficient energy transfer within mitochondria.
NAD⁺ also plays a crucial role in DNA repair and genome stability. It is required by enzymes such as PARPs (poly ADP-ribose polymerases), which detect and repair damaged DNA. This function helps protect cells from genetic mutations and supports long-term cellular health.
In addition, NAD⁺ is closely involved in regulating sirtuin proteins, a family of enzymes linked to aging, inflammation, and metabolic control. By activating sirtuins, NAD⁺ influences processes such as mitochondrial function, stress resistance, and inflammation reduction. This has made NAD⁺ a major focus in aging and longevity research.
NAD⁺ is also used in cell signaling pathways, where it acts as a substrate for enzymes involved in calcium signaling and immune response regulation. These functions help cells communicate and respond to environmental stress.
In medical and research contexts, NAD⁺ and its precursors are studied for their potential applications in metabolic disorders, neurodegenerative diseases, and age-related decline. Researchers are exploring how increasing NAD⁺ levels may support energy metabolism, cognitive function, and cellular repair mechanisms.
Overall, NAD⁺ is essential for energy metabolism, DNA maintenance, cellular signaling, and aging-related processes, making it one of the most important molecules in biological systems.
