Neuromedin S (human) CAS NO.1138204-27-9
Neuromedin S (human) CAS NO.1138204-27-9
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Neuromedin S (human) |
| CAS NO. | 1138204-27-9 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C173H265N53O44 |
| Molecular Weight | 3791.37g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1 % v/v). For best results, first dissolve in a small volume of 0.1 % acetic acid or sterile water to prepare a 0.1–0.5 mg/mL stock solution, then dilute with the desired assay buffer. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Human Neuromedin S is an endogenous neuropeptide that acts as a high-affinity agonist at the neuromedin U receptor 2 (NMUR2). It plays crucial roles in regulating circadian rhythms, energy homeostasis, appetite suppression, and stress responses. Its bioactivity is dependent on its correctly folded disulfide-bonded structure and can be validated in NMUR2-expressing cell-based assays (e.g., calcium flux or cAMP inhibition). |
| Storage Conditions | Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80 °C. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide exerts its biological effects by binding with high affinity and selectivity to the G protein-coupled receptor NMUR2, primarily coupling to Gq/11 proteins. Activation stimulates phospholipase C, leading to inositol trisphosphate (IP3) production, intracellular calcium mobilization, and inhibition of cAMP accumulation. This signaling cascade modulates diverse physiological processes including suprachiasmatic nucleus activity, food intake suppression, energy expenditure, and neuroendocrine stress responses. The human-specific sequence with intact disulfide bonds ensures accurate representation of native NMU signaling in human cell-based assays and translational research models.
2.PRODUCT INDICATIONS
Neuromedin S (human) is indicated exclusively for research applications in studies of human neuropeptide signaling and physiology. It is employed to investigate NMU's roles in circadian rhythm regulation, energy metabolism, appetite suppression, stress responses, and potential involvement in metabolic disorders. The product serves as a reference agonist for validating human NMUR2 expression, screening receptor modulators, and characterizing NMU signaling pathways in human cell lines and translational models. It is not intended for diagnostic, therapeutic, or clinical use in humans.
3.CLINICAL EFFICACY OF PRODUCT
As a research reagent, Neuromedin S (human) has no established clinical efficacy or safety profile for therapeutic applications. The peptide has not undergone clinical trials, regulatory approval, or safety evaluation for any medical indication. While it contributes to fundamental understanding of human NMU biology and identifies potential therapeutic targets for circadian disorders, obesity, and metabolic syndrome, its utility remains confined to laboratory research. Any clinical translation would require development of optimized therapeutics with comprehensive preclinical and clinical testing.
4.DELIVERY & SHIPPING
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Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight
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