Neuromedin (U25), human CAS NO.312306-89-1
Neuromedin (U25), human CAS NO.312306-89-1
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Neuromedin (U25), human |
| CAS NO. | 312306-89-1 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C141H203N41O38 |
| Molecular Weight | 3080.44g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). For best results, first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Human Neuromedin U-25 is an endogenous neuropeptide that acts as a potent agonist at the neuromedin U receptors (NMUR1 and NMUR2). It regulates diverse physiological functions including energy homeostasis, appetite suppression, smooth muscle contraction, stress response, and circadian rhythms. Activity can be confirmed in NMUR-expressing cell-based assays (e.g., calcium flux or cAMP inhibition). |
| Storage Conditions | Lyophilized powder: Store desiccated at –20°C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20°C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80°C |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide exerts its effects by binding with high affinity to G protein-coupled receptors NMUR1 and NMUR2, primarily coupling to Gq/11 proteins. Activation stimulates phospholipase C, leading to inositol trisphosphate (IP3) production, intracellular calcium mobilization, and inhibition of cAMP accumulation. This signaling cascade modulates diverse physiological processes including smooth muscle contraction, appetite suppression, energy expenditure, and neuroendocrine responses. The human-specific sequence ensures accurate representation of native NMU signaling in human-derived cell systems and translational research models.
2.PRODUCT INDICATIONS
Neuromedin U-25, human is indicated exclusively for research applications in studies of human neuropeptide signaling and physiology. It is employed to investigate NMU's roles in human energy metabolism, appetite control, gastrointestinal motility, stress responses, and potential involvement in metabolic disorders. The product serves as a reference agonist for validating human NMUR1/NMUR2 expression, screening receptor modulators, and characterizing NMU signaling pathways in human cell lines and translational models. It is not intended for diagnostic, therapeutic, or clinical use in humans.
3.CLINICAL EFFICACY OF PRODUCT
As a research reagent, Neuromedin U-25, human has no established clinical efficacy or safety profile for therapeutic applications. The peptide has not undergone clinical trials, regulatory approval, or safety evaluation for any medical indication. While it contributes to fundamental understanding of human NMU biology and identifies potential therapeutic targets for obesity, metabolic syndrome, and gastrointestinal disorders, its utility remains confined to laboratory research. Any clinical translation would require development of optimized therapeutics with comprehensive preclinical and clinical testing.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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