Name: High-Purity Neuropeptide EI-Gly-Arg-Arg-MCH for MCH Research
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Neuropeptide EI-Gly-Arg-Arg-MCH (human, mouse, rat)

Neuropeptide EI-Gly-Arg-Arg-MCH (Human, Mouse, Rat) is a high-purity synthetic peptide fragment derived from the Melanin-Concentrating Hormone (MCH) precursor, engineered with a specific C-terminal extension. Characterized by the molecular formula C₁₈₂H₂₈₂N₅₄O₅₂S₄ and a precise molecular weight of 4186.86 Da, this peptide serves as a critical research tool for studying energy homeostasis and neuromodulation. While a specific CAS Number may be assigned based on proprietary synthesis, this product is essential for investigating the structure-activity relationships of MCH receptors (MCHR1/MCHR2). It is widely used in pharmacological assays to understand the mechanisms behind obesity, depression, and sleep disorders.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neuropeptide EI-Gly-Arg-Arg-MCH (human, mouse, rat)
CAS NO.	\
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₈₂H₂₈₂N₅₄O₅₂S₄
Amino Acid Sequence	Gly-Arg-Arg
Purity (RP-HPLC)	≥98%
Solubility	This peptide exhibits good solubility in sterile distilled water, PBS (Phosphate Buffered Saline), and acetic acid solutions.
Endotoxin	≤1.0 EU/mg
Biological Activity	This neuropeptide functions as a potent agonist/antagonist (depending on context) within the central nervous system. It is validated for use in receptor binding assays, calcium flux assays, and neurotransmitter release studies. It demonstrates high affinity for MCHR1 and MCHR2 receptors, making it a critical tool for studying obesity, depression, and sleep regulation mechanisms.
Storage Conditions	Store the lyophilized powder at -20°C for long-term stability.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Receptor Interaction: The peptide binds selectively to Melanin-Concentrating Hormone receptors (MCHR1 and MCHR2), which are G-protein coupled receptors (GPCRs) found in the central nervous system.

Signal Transduction: Upon binding, it modulates intracellular signaling pathways, primarily inhibiting adenylate cyclase activity and reducing cAMP levels, leading to downstream physiological effects.

Neuromodulation: It functions by mimicking or blocking the action of endogenous MCH, thereby influencing the release of other neurotransmitters and neuropeptides involved in appetite and mood regulation.

2.PRODUCT INDICATIONS

Research Use Only (RUO): Strictly intended for scientific research and laboratory experimentation, not for human therapeutic use.

Pharmacological Assays: Ideal for use as a standard or agonist/antagonist in receptor binding assays, functional activity assays (e.g., calcium mobilization), and competitive inhibition studies.

Neuroscience Research: Essential for studying the neurobiology of feeding behavior, energy balance, and sleep-wake cycles in rodent models.

Drug Discovery: Serves as a reference compound in the screening and development of novel therapeutics targeting MCH receptors for obesity and psychiatric disorders.

3.CLINICAL EFFICACY OF PRODUCT

High Research Value: Demonstrates high biological activity and specificity, providing researchers with reliable data for understanding the pathophysiology of metabolic and mood disorders.

Translational Relevance: By studying this peptide, researchers can identify potential biomarkers and therapeutic targets for conditions such as depression, anxiety, and insomnia.

Consistency in Data: The defined molecular structure (4186.86 Da) ensures reproducible results in in vitro and ex vivo experiments, which is crucial for pre-clinical validation and the development of clinical diagnostics.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.