Name: High-Purity Neuropeptide EI: MCH Antagonist & MSH Agonist
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Neuropeptide EI (human, mouse, rat) CAS NO.125934-45-4

Neuropeptide EI (human, mouse, rat) (CAS 125934-45-4) is a high-purity (up to ≥99% HPLC-MS verified) dual-activity peptide with molecular formula C₆₃H₉₈N₁₆O₂₃ and molecular weight 1447.58 g/mol. As an MCH antagonist and MSH agonist, it regulates circadian rhythm and modulates neurobehavioral responses, ideal for cross-species neuroscience and endocrinology research. We are a trusted NEI peptide supplier, offering custom MCH antagonist peptide service, bulk order options (5 mg–100 mg), low endotoxin, and stable storage properties, with global shipping and rigorous batch-specific quality control.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neuropeptide EI (human, mouse, rat)
CAS NO.	125934-45-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C₆₃H₉₈N₁₆O₂₃
Molecular Weight	g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in sterile water and DMSO
Endotoxin	< 1.0 EU/mg
Biological Activity	Dual-activity peptide: Melanin-Concentrating Hormone (MCH) antagonist and Melanocyte Stimulating Hormone (MSH) agonist; regulates circadian rhythmicity of plasma ACTH levels, induces grooming/locomotion behaviors, modulates catecholamine metabolism and release; acts on melanocortin receptors and MCH receptors (MCHR)
Storage Conditions	-20±5℃ for short-term storage (2-3 years)
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Neuropeptide EI (NEI) is a 13-amino acid, C-terminally amidated peptide with conserved activity across human, mouse, and rat species, exerting dual biological effects as a Melanin-Concentrating Hormone (MCH) antagonist and Melanocyte Stimulating Hormone (MSH) agonist. It acts by interacting with two key receptor families: it competitively binds to MCH receptors (MCHR) to block MCH-mediated signaling, while activating melanocortin receptors (MCRs) to trigger MSH-related pathways. Upon receptor activation, it modulates intracellular signaling cascades, including cyclic adenosine monophosphate (cAMP) production and calcium ion homeostasis, to regulate physiological processes.

2.PRODUCT INDICATIONS

Investigation of MCH and MSH receptor signaling pathways, as well as their crosstalk in neuroendocrine regulation and behavioral modulation

Screening and validation of MCHR antagonists and MCR agonists via in vitro assays (receptor binding, cAMP detection, and calcium mobilization assays)

Study of circadian rhythm regulation, particularly the rhythmic secretion of ACTH and its link to neuroendocrine homeostasis using human, mouse, and rat models

Research on behavioral neuroscience, including grooming, locomotion, and stress responses, by targeting NEI-mediated signaling pathways

3.CLINICAL EFFICACY OF PRODUCT

In receptor-based assays, it serves as a reliable positive control and reference standard to evaluate the potency of MCHR/MCR-targeted drug candidates for neuroendocrine and behavioral disorders

In mouse and rat models of circadian rhythm disorders, it aids in elucidating the role of NEI in ACTH rhythmicity, supporting the development of novel therapeutics for sleep-wake cycle disturbances

It facilitates the characterization of melanocortin and MCH pathway interactions, providing insights for developing treatments for obesity, anxiety, and stress-related neurological disorders

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.