Name: High-Purity Neuropeptide K for Cardiovascular & Metabolic Research
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Neuropeptide K, porcine CAS NO.106441-70-7

Neuropeptide K, porcine (CAS 106441-70-7) is a high-purity (up to ≥98% RP-HPLC) tachykinin family peptide with molecular formula C₁₇₅H₂₈₄N₅₂O₅₂S and molecular weight 5980.6 g/mol. As a multi-functional neuropeptide, it acts as a potent vasodilator and anorexigenic agent, ideal for cardiovascular, neuroscience, and metabolic research. We are a trusted porcine NPK peptide supplier, offering custom TFA-free peptide service, bulk order options (1 mg–10 g), low endotoxin, and stable storage properties, with global shipping and rigorous batch-specific quality control.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neuropeptide K, porcine
CAS NO.	106441-70-7
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₇₅H₂₈₄N₅₂O₅₂S
Molecular Weight	5980.6g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in distilled water (up to 2 mg/mL); soluble in DMSO, dilute acid; slightly soluble in ethanol
Endotoxin	< 1.0 EU/mg
Biological Activity	Member of the tachykinin family; acts as a potent vasodilator, secretagogue, and cardio-modulatory peptide; exhibits anorexigenic activity (decreases food intake in vivo); excites neurons and provokes behavioral responses; can be cleaved to release Neurokinin A; binds to tachykinin receptors
Storage Conditions	-20℃ for short-term storage
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Neuropeptide K, porcine is a 36-amino acid, C-terminally amidated member of the tachykinin peptide family, exerting diverse physiological effects via binding to tachykinin receptors (NK1 and NK2). As a multi-functional neuropeptide, it activates G-protein coupled receptor (GPCR)-mediated intracellular signaling pathways upon receptor ligation: binding to NK1/NK2 receptors triggers hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2), generating inositol trisphosphate (IP3) and diacylglycerol (DAG), which elevate intracellular calcium levels to mediate downstream responses.

2.PRODUCT INDICATIONS

Investigation of tachykinin receptor (NK1/NK2) signaling pathways and their roles in vasodilation, neurotransmission, and hormone secretion

Screening and validation of tachykinin receptor agonists/antagonists via in vitro assays (receptor binding, calcium mobilization, and smooth muscle relaxation assays)

Study of species-specific tachykinin family biology using porcine models to elucidate Neuropeptide K-mediated physiological processes

3.CLINICAL EFFICACY OF PRODUCT

In vascular smooth muscle assays, it serves as a reliable positive control to evaluate the efficacy of tachykinin-targeted drugs for cardiovascular disorders (e.g., hypertension, vasospasm)

In porcine and rodent models of metabolic disorders, it aids in elucidating the role of Neuropeptide K in appetite suppression, supporting the development of novel therapeutics for obesity and eating disorders

It facilitates the characterization of tachykinin signaling in neuronal excitation and neurotransmitter release, providing insights for developing treatments for neurological disorders linked to dysregulated tachykinin pathways

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.