Name: Buy Neurotensin CAS 39379-15-2 & 55508-42-4 - High Purity
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Neurotensin CAS NO.39379-15-2/CAS NO.55508-42-4

Neurotensin is a 13-amino acid neuropeptide with an N-terminal pyroglutamate and free C-terminal carboxyl group, supplied as a lyophilized powder with ≥95% HPLC purity and low endotoxin levels. This research-grade peptide functions as a neurotransmitter and neuromodulator, primarily targeting neurotensin receptors NTSR1 and NTSR2. It is widely used to study central and peripheral effects including dopaminergic signaling, gastrointestinal motility, pain modulation, and thermoregulation. The product serves as a critical tool for investigating neuropsychiatric disorders, metabolic regulation, and cancer biology, providing researchers with a reliable reagent for both in vitroand in vivopreclinical studies.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neurotensin
CAS NO.	39379-15-2/55508-42-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C78H121N21O20
Molecular Weight	1672.96g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	Neurotensin is a tridecapeptide neurotransmitter and neuromodulator that acts primarily through the neurotensin receptors NTSR1 (high affinity) and NTSR2. It elicits diverse biological effects, including hypotension, hyperglycemia, hypothermia, and modulation of dopaminergic signaling. Biological activity is typically confirmed by receptor binding assays (e.g., competitive binding to NTSR1) or functional assays (e.g., calcium flux in NTSR1-expressing cells).
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80 °C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Neurotensin exerts its biological effects by binding with high affinity to G protein-coupled receptors NTSR1 and NTSR2, primarily activating Gq/11 signaling pathways that stimulate phospholipase C and increase intracellular calcium mobilization. This activation modulates downstream effectors including protein kinase C and mitogen-activated protein kinases, leading to diverse physiological responses such as dopamine release, smooth muscle contraction, and cell proliferation. The peptide also exhibits cross-talk with other neurotransmitter systems and can influence pain perception, thermoregulation, and gastrointestinal function through its action on central and peripheral receptors.

2.PRODUCT INDICATIONS

This peptide is indicated for research applications focused on neuropsychiatric disorders, gastrointestinal physiology, pain modulation, and cancer biology. It is utilized in in vitroassays with NTSR1/NTSR2-expressing cells to study receptor binding, calcium flux, and intracellular signaling pathways. In in vivostudies, it is administered to investigate dopaminergic transmission, feeding behavior, nociception, and tumor growth in preclinical models. The product also serves as a reference standard for immunohistochemistry, autoradiography, and functional studies to localize neurotensin receptor expression and activity in brain regions, gut tissues, and cancer cells.

3.CLINICAL EFFICACY OF PRODUCT

Neurotensin has no clinical efficacy or safety profile, as it is strictly a research reagent for preclinical investigations. The peptide has not undergone clinical trials, regulatory evaluation, or safety assessment for diagnostic or therapeutic use in humans. While preclinical studies demonstrate its potent effects on dopamine signaling, pain perception, and cancer cell proliferation, these findings remain exploratory and have not been translated into validated clinical interventions. Any potential therapeutic applications would require the development of stable analogs with comprehensive pharmacokinetic and safety evaluations.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.