Name: [Nle4] a-MSH Amide – Potent Melanocyte-Stimulating Peptide
Availability: InStock
Rating: 4.5 (89 reviews)

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[Nle4] a-MSH, amide

[Nle4] α-MSH, amide is a synthetic, stabilized analog of α-Melanocyte-Stimulating Hormone (α-MSH). This research-grade peptide incorporates two key modifications: a norleucine (Nle) substitution at position 4, replacing the oxidation-sensitive methionine, and a C-terminal amidation. These features significantly enhance its chemical stability, biological half-life, and receptor binding affinity, making it a superior and reliable tool for studying melanocortin receptor (MC1R) pharmacology and related physiological processes.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Nle⁴]-α-MSH, amide
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C78H111N21O19
Molecular Weight	1646.88g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥50 mg/mL), dilute acetic acid, or 1% ammonium hydroxide
Endotoxin	< 1.0 EU/mg
Biological Activity	Potent agonist of melanocortin receptors (MC1R, MC3R, MC4R, MC5R); induces melanogenesis and regulates energy metabolism
Storage Conditions	Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This analog acts as a potent agonist primarily at the melanocortin 1 receptor (MC1R). The norleucine substitution provides superior oxidation resistance and may enhance hydrophobic interactions within the receptor binding pocket. The C-terminal amidation protects against carboxypeptidase degradation.

2.PRODUCT INDICATIONS

This product is indicated for high-fidelity research in dermatology, pharmacology, and cell signaling. Its primary applications include: studying MC1R-mediated melanogenesis and skin pigmentation, investigating the anti-inflammatory and immunomodulatory effects of α-MSH, serving as a stable reference agonist in receptor binding and functional (cAMP) assays, and exploring the role of melanocortin signaling in skin cancer, inflammation, and neuroprotection models.

3.CLINICAL EFFICACY OF PRODUCT

[Nle4] α-MSH, amide is a foundational research compound. While not an approved drug itself, its design principles are directly relevant to clinical development. The enhanced stability and potency of this analog have made it a critical tool for validating MC1R as a therapeutic target. Its structural concept underpins clinically investigated and approved analogs (e.g., afamelanotide) for treating light-sensitive skin disorders and vitiligo, demonstrating its direct translational relevance.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.