TECHNICAL SPECIFICATIONS

1.MECHANISM OF ACTION

The mechanism of action of Notoginsenoside Fc involves a multi-targeted approach to protect vascular and renal health. It primarily functions by upregulating the expression of peroxisome proliferator-activated receptor-gamma (PPAR-γ), which helps attenuate high glucose-induced vascular endothelial cell injury by inhibiting apoptosis and reducing the production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. Additionally, it modulates the HMGCS2 pathway to ameliorate mitochondrial dysfunction and glomerular endothelial cell pyroptosis in diabetic nephropathy. In platelets, it exerts its anti-thrombotic effect by downregulating the PLCγ2 signaling cascade, thereby suppressing platelet aggregation without significantly altering basal calcium levels.

2.PRODUCT INDICATIONS

Notoginsenoside Fc is indicated for the prevention and treatment of vascular complications associated with diabetes and metabolic disorders. It is particularly beneficial for individuals with diabetic nephropathy, as it helps reduce urinary microalbumin levels and ameliorates kidney dysfunction. The product is also indicated for conditions involving vascular endothelial injury, such as atherosclerosis and vasculopathy, and has shown potential in treating acute kidney injury by regulating the SIRT3/SOD2 pathway to protect renal tubular cells. Its anti-platelet aggregation properties make it suitable for managing thrombotic diseases, including arterial and venous thrombosis.

3.CLINICAL EFFICACY OF PRODUCT

Clinical and pre-clinical studies have demonstrated the significant efficacy of Notoginsenoside Fc in improving vascular and renal outcomes. In diabetic models, it has been shown to accelerate reendothelialization following vascular injury by promoting endothelial cell autophagy, thereby reducing neointimal formation. It effectively ameliorates renal tubular injury and mitochondrial damage in acute kidney injury models, leading to decreased levels of serum creatinine and blood urea nitrogen. Furthermore, its ability to protect against high glucose-induced endothelial cell injury and its renoprotective effects in diabetic nephropathy highlight its therapeutic potential for patients with diabetes-related complications.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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If you have any product requirements, please send an email to:info@huanqiukeji9.com;whatsapp:85246842553