Octaneuropeptide

Octaneuropeptide

Octaneuropeptide

Octaneuropeptide

Octaneuropeptide

Octaneuropeptide (OP), also known as the Octadecaneuropeptide, is a synthetic neuropeptide derived from the processing of the larger precursor protein, diazepam-binding inhibitor (DBI). This endogenous 18-amino acid peptide (QATVGDVNTDRPGLLDLK) is a high-purity research tool, recognized for its central role in modulating anxiety, stress responses, and neuroendocrine functions, particularly within the GABAergic system of the brain.



TECHNICAL SPECIFICATIONS


Item
Specification
Product Name
Octaneuropeptide 
CAS NO.
/
Appearance
White to off-white lyophilized powder
Molecular Formula
C41H74N12O11
Molecular Weight
 911.1/mol 
Purity (RP-HPLC)
≥98%
Solubility

Soluble in water (≥1 mg/mL), 0.1% TFA aqueous solution, dilute acetic acid and DMSO

Endotoxin≤1.0 EU/mg
Biological Activity
Potent regulator of astroglial calcium signaling (PLC-dependent Ca²⁺ mobilization, EC₅₀ ≈ 0.5–3.0 nM)
Storage Conditions
Store at ≤ -20°C in a dry, dark, sealed container.
Stock Location
Stock in USA
MOQ
1g


1.MECHANISM OF ACTION

Octaneuropeptide exerts its effects primarily through interactions with the central-type benzodiazepine receptors (CBR), which are located on the mitochondrial membrane and are part of the mitochondrial permeability transition pore (MPTP). By binding to these receptors, OP antagonizes the action of endozepines, modulates mitochondrial function, and influences GABA_A receptor activity indirectly. 


2.PRODUCT INDICATIONS

This product is indicated for advanced neurobiological and pharmacological research. Key applications include: studying the molecular mechanisms of anxiety, stress, and neuroendocrine regulation, investigating the role of the endozepine/OP system in brain disorders, evaluating its effects on food intake and metabolism in rodent models, and serving as a reference peptide in receptor binding studies to characterize CBR-mediated signaling pathways.


3.CLINICAL EFFICACY OF PRODUCT

Octaneuropeptide is a research-grade neuropeptide and not a direct clinical therapeutic. Its "efficacy" lies in its critical role as an endogenous modulator of brain function, providing a valuable model for understanding anxiety and stress disorders at the molecular level. 


4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods 
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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