Name: Octa(OtBu)-Glu(AEEA-AEEA-OSu)-OtBu: High-Purity Peptide Reagent
Availability: InStock
Rating: 4.5 (89 reviews)

english

Octa(OtBu)-Glu(AEEA-AEEA-OSu)-OtBu CAS NO.1118767-15-9

Octa(OtBu)-Glu(AEEA-AEEA-OSu)-OtBu CAS NO.1118767-15-9

Octa(OtBu)-Glu(AEEA-AEEA-OSu)-OtBu (CAS NO. 1118767-15-9) is a highly functionalized chemical building block designed for advanced bioconjugation, peptide synthesis, and surface modification applications. This specialized compound combines multiple orthogonally protected functional groups—including two AEEA hydrophilic spacers, an N-hydroxysuccinimide (NHS) activated ester, and tert-butyl ester (OtBu) protecting groups—enabling controlled, site-specific chemical modifications. Available as a white to off-white crystalline solid with HPLC-verified purity ≥95%, it provides researchers and formulators with a versatile tool for constructing complex molecular architectures, developing targeted delivery systems, and creating advanced materials with tailored properties.

Send Email

Download

TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Octa(OtBu)-Glu(AEEA-AEEA-OSu)-OtBu
CAS NO.	1118767-15-9
Appearance	White to off-white crystalline or waxy solid
Molecular Formula	C₄₀H₆₀N₄O₁₀S
Molecular Weight	760.0 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in DMF, DMSO, acetonitrile; partially soluble in ethanol
Endotoxin	< 1.0 EU/mg (if for research/analytical grade)
Biological Activity	Functionalized linker/building block; contains AEEA spacer, activated ester (OSu), and multiple OtBu protecting groups for bioconjugation and solid-phase synthesis
Storage Conditions	Store at -20°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This compound functions as a multifunctional linker and conjugation reagent. The NHS-activated ester (OSu) reacts efficiently with primary amines under mild aqueous conditions to form stable amide bonds, enabling covalent attachment to proteins, peptides, or amine-functionalized surfaces. The dual AEEA spacers provide extended hydrophilic spacing that reduces steric hindrance and enhances solubility. The multiple OtBu protecting groups allow selective deprotection and sequential functionalization, enabling precise stepwise assembly of complex molecular structures. This combination of reactive handles and protective groups makes it an ideal platform for controlled chemical synthesis and bioconjugation strategies.

2.PRODUCT INDICATIONS

Bioconjugation Chemistry: Preparation of antibody-drug conjugates (ADCs), protein-polymer conjugates, and diagnostic probes

Peptide Synthesis: Advanced building block for solid-phase peptide synthesis with orthogonal protection strategies

Surface Functionalization: Modification of nanoparticles, biosensors, and chromatography supports with specific reactive groups

Drug Delivery Systems: Development of targeted delivery platforms and controlled release formulations

Materials Science: Creation of functional polymers, hydrogels, and smart materials with tailored properties

Diagnostic Development: Construction of immunoassays, biosensors, and molecular imaging agents

3.CLINICAL EFFICACY OF PRODUCT

Conjugation Efficiency: Demonstrated high coupling yields (>90%) with various amine-containing biomolecules under optimized conditions

Synthesis Versatility: Proven effectiveness in multi-step synthesis protocols requiring orthogonal protection strategies

Product Stability: Enhanced stability of conjugates through optimized spacer design and robust chemical linkages

Research Reproducibility: Consistent batch-to-batch performance ensures reliable experimental outcomes

Application Success: Successfully utilized in developing targeted therapeutics, diagnostic platforms, and advanced materials

Quality Assurance: Meets stringent analytical standards for purity, stability, and functional group integrity

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.