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Pentagastrin CAS NO.5534-95-2

Pentagastrin (CAS NO. 5534-95-2) is a synthetic pentapeptide analog of gastrin, widely used as a diagnostic agent and research tool for gastrointestinal physiology. Its molecular formula is C₃₇H₄₉N₇O₉S, with a molecular weight of 771.90 g/mol. This white to off-white crystalline powder exhibits high purity (≥98% by RP-HPLC) and acts as a potent agonist of the gastrin/cholecystokinin B (CCK-B) receptor, making it essential for gastric acid secretion testing and related research applications.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Pentagastrin
CAS NO.	5534-95-2
Appearance	White to off-white crystalline powder
Molecular Formula	C₃₇H₄₉N₇O₉S
Molecular Weight	767.89 g/mol
Amino Acid Sequence	β-Ala-Trp-Met-Asp-Phe-NH₂
Purity (RP-HPLC)	≥98.0%
Solubility	Soluble in water, methanol, and dimethyl sulfoxide (DMSO)
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent agonist of the gastrin/cholecystokinin B (CCK-B) receptor; stimulates gastric acid secretion and mucosal growth
Storage Conditions	Store at -20°C in a dry, dark environment; protect from moisture and light
Stock Location	Stock in USA
MOQ	[Your Minimum Order Quantity, e.g., 50 mg / 1 g]

1.MECHANISM OF ACTION

Pentagastrin is a synthetic pentapeptide analog of gastrin, acting as a potent and selective agonist for the gastrin/cholecystokinin B (CCK-B) receptor. By binding to these receptors on parietal cells in the stomach, it stimulates the secretion of gastric acid, pepsin, and intrinsic factor. It also promotes mucosal growth and motility in the gastrointestinal tract. Unlike endogenous gastrin, its synthetic structure ensures high stability and consistent biological activity, making it ideal for diagnostic and research use.

2.PRODUCT INDICATIONS

Pentagastrin is primarily used as a diagnostic agent to assess gastric acid secretion capacity in patients with suspected disorders of the upper gastrointestinal tract, such as Zollinger-Ellison syndrome, pernicious anemia, and hypochlorhydria. It is also employed in research settings to study gastric physiology, evaluate mucosal integrity, and screen for compounds targeting the CCK-B receptor. Additionally, it may be used to stimulate gallbladder contraction in certain diagnostic procedures.

3.CLINICAL EFFICACY OF PRODUCT

Clinical studies have established Pentagastrin as a reliable standard for gastric acid stimulation tests. It consistently induces a robust and measurable acid response, enabling accurate diagnosis of hypo- or hyper-secretory states. Its rapid onset of action (within 10–15 minutes) and short duration of effect (peak response at 30 minutes) allow for efficient testing protocols. The product exhibits a favorable safety profile, with mild, transient side effects such as abdominal cramps, nausea, or flushing that resolve spontaneously. No significant systemic toxicity or immunogenicity has been reported in clinical use.

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