pinocembrin CAS NO.480-39-7
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Pinocembrin |
| CAS NO. | 480-39-7 |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | 304.25 g/mol |
| Molecular Weight | 870.01 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in DMSO, methanol, ethanol; slightly soluble in water |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Exhibits antioxidant, anti-inflammatory, and neuroprotective activities (in vitro data) |
| Storage Conditions | Store at -20°C, protected from light and moisture; avoid freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Pinocembrin exerts its effects through multiple molecular pathways. It acts as a competitive inhibitor of histidine decarboxylase (HDC), reducing histamine production and modulating allergic responses. Its neuro- and cardioprotective actions are mediated via activation of the Nrf2 antioxidant pathway, enhancement of mitochondrial function (improving ATP synthesis and reducing ROS), and inhibition of NF-κB-driven inflammation. Additionally, it modulates PI3K/Akt and MAPK signaling to promote cell survival and has been shown to induce apoptosis and autophagy in certain cancer cells through caspase-3 and LC3-II regulation.
2.PRODUCT INDICATIONS
- Neuropharmacology Research: Investigation of neuroprotective effects in models of cerebral ischemia, stroke, Alzheimer's disease, and Parkinson's disease.
- Anti-inflammatory & Allergy Studies: Used as a tool compound to study HDC inhibition and mast cell stabilization.
- Cosmeceutical Development: Exploration of antioxidant and anti-aging properties in skin care formulations.
- Pharmaceutical QC: Serving as a certified reference standard for the authentication and quantification of propolis extracts and related herbal products.
3.CLINICAL EFFICACY OF PRODUCT
Extensive preclinical data supports the therapeutic potential of Pinocembrin. In animal models, it significantly reduces infarct volume in cerebral ischemia, improves cognitive function, and demonstrates hepatoprotective and cardioprotective effects against toxin-induced damage. Notably, a pinocembrin injection has been approved in China as a Class I new drug for clinical trials targeting acute ischemic stroke, highlighting its translational promise. While human clinical data is still emerging, its efficacy in reducing oxidative stress and inflammation is well-established in vitro and in vivo
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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