Name: Polistes Mastoparan - Natural Wasp Venom for Pain Relief
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Polistes Mastoparan CAS NO.74129-19-4

Polistes Mastoparan (CAS NO. 74129-19-4) is a synthetic, linear 14-amino acid peptide toxin originally isolated from the venom of Polisteswasps. This amphipathic, α-helix-forming peptide is a high-purity research tool renowned for its potent, direct activation of G-proteins and its ability to permeabilize cell membranes, making it invaluable for studying cell signaling and membrane biology.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Polistes Mastoparan
CAS NO.	74129-19-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C77H127N21O18
Molecular Weight	1635g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, 0.1 M acetic acid, or DMSO at a concentration ≥ 1 mg/mL
Endotoxin	< 1.0 EU/mg
Biological Activity	Binds to and inhibits calmodulin (CaM); activates phospholipase A₂; exhibits antimicrobial activity against S. aureus (EC₅₀ = 5 μM) by inducing K⁺ efflux; promotes mast cell degranulation and histamine release.
Storage Conditions	Store long-term at -20°C to -80°C; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide exerts its effects through two primary mechanisms. First, it directly binds to and activates pertussis toxin-sensitive heterotrimeric G proteins (Gi/o family), stimulating GTPase activity and downstream signaling without receptor involvement. Second, its cationic and amphipathic structure allows it to insert into phospholipid bilayers, disrupting membrane integrity, forming pores, and facilitating calcium influx and mast cell degranulation.

2.PRODUCT INDICATIONS

This product is indicated for fundamental research in pharmacology, cell biology, and biochemistry. It serves as a critical tool for: investigating non-receptor-mediated G-protein signaling pathways, studying mast cell and basophil activation and histamine release, probing mechanisms of antimicrobial peptides (AMPs), and as a model compound for researching peptide-lipid interactions and membrane poration.

3.CLINICAL EFFICACY OF PRODUCT

Polistes Mastoparan itself is not used as a therapeutic agent. Its efficacy lies in its robust and reliable activity as a research probe. Studies utilizing this peptide have significantly advanced the understanding of G-protein function and membrane disruption, providing foundational knowledge that informs the design of novel drug candidates, including antimicrobial agents and targeted cell-penetrating peptides in preclinical development.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.