Name: Polybia-MP1 CAS 872043-01-1: Powerful Antimicrobial Peptide
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Polybia-MP1 CAS NO.872043-01-1

Polybia-MP1 is a cationic amphipathic peptide derived from the venom of the Brazilian wasp Polybia paulista, belonging to the mastoparan family. It is widely recognized for its dual-functionality as a potent antimicrobial agent and a selective anticancer peptide. With its ability to preferentially target microbial and cancer cell membranes while displaying low cytotoxicity towards normal mammalian cells, it serves as a high-value research tool for developing novel anti-infective and anti-tumor therapeutic strategies.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Polybia-MP1
CAS NO.	872043-01-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C78H132N20O19
Molecular Weight	1685.0g/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in water, 0.1 M acetic acid, or 10% DMSO solution
Endotoxin	<1 EU/mg
Biological Activity	Potent antimicrobial and anticancer peptide; selectively targets microbial and cancer cell membranes via electrostatic interaction with anionic phospholipids, causing membrane disruption and cell death
Storage Conditions	Store at -20°C, protected from light and moisture; stable for at least 2 years
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide operates via a membrane-disruptive mechanism driven by electrostatic interactions. Its cationic nature allows it to bind selectively to anionic phospholipids, such as phosphatidylserine (PS) and phosphatidylethanolamine (PE), which are abnormally exposed on the outer leaflets of cancer cells and bacterial membranes. This binding induces the formation of toroidal pores, leading to rapid membrane permeabilization, ion leakage, and ultimately, cell lysis. The synergy between PS and PE significantly amplifies pore formation, underpinning its selective toxicity.

2.PRODUCT INDICATIONS

This product is indicated for preclinical research in oncology, microbiology, and drug discovery. It is utilized to study novel cancer therapies targeting prostate, bladder, and leukemic cells, as well as to combat multidrug-resistant bacterial and fungal infections. Researchers employ it in structural-activity relationship (SAR) studies to engineer analogs with enhanced selectivity, and in biophysical assays to investigate membrane-peptide interactions.

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3.CLINICAL EFFICACY OF PRODUCT

Preclinical studies demonstrate that Polybia-MP1 exhibits potent cytotoxic activity against various cancer cell lines (e.g., IC50 ~11–37 µM for PC-3, Biu87) and broad-spectrum antimicrobial effects (MIC 4–32 µM). Importantly, it shows high selectivity by causing minimal hemolysis to healthy red blood cells, validating its potential as a safe and effective lead compound for targeted therapies against resistant pathogens and tumors.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: PolybiaMP1 #AntimicrobialPeptide #AnticancerPeptide #WaspVenom #MembraneDisruption #DrugDiscovery #OncologyResearch #SelectiveToxicity

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